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  Dynamic, adaptive changes in MAO-A binding after alterations in substrate availability: An in vivo [(11)C]-harmine positron emission tomography study

Sacher, J., Rabiner, E. A., Clark, M., Rusjan, P., Soliman, A., Boskovic, R., et al. (2012). Dynamic, adaptive changes in MAO-A binding after alterations in substrate availability: An in vivo [(11)C]-harmine positron emission tomography study. Journal of Cerebral Blood Flow and Metabolism, 32(3), 443-446. doi:10.1038/jcbfm.2011.184.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-000F-43B8-0 Version Permalink: https://hdl.handle.net/21.11116/0000-0004-5C0D-8
Genre: Journal Article

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Sacher_2012_Dynamic.pdf (Publisher version), 235KB
 
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 Creators:
Sacher, Julia1, 2, 3, 4, Author           
Rabiner, Eugenii A.5, Author
Clark, Michael1, 2, Author
Rusjan, Pablo1, Author
Soliman, Alexandra1, 2, Author
Boskovic, Rada1, 5, 6, Author
Kish, Stephen J.1, Author
Wilson, Alan A.1, Author
Houle, Sylvain1, Author
Meyer, Jeffrey H.1, 2, Author
Affiliations:
1Vivian M. Rakoff PET Centre, Centre for Addiction and Mental Health, University of Toronto, ON, Canada, ou_persistent22              
2Mood and Anxiety Disorders Division, Centre for Addiction and Mental Health, University of Toronto, ON, Canada, ou_persistent22              
3Clinic for Cognitive Neurology, University of Leipzig, Germany, ou_persistent22              
4Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, Leipzig, DE, ou_634549              
5GlaxoSmithKline, Toronto, ON, Canada, ou_persistent22              
6Clinical Pharmacology and Toxicology Division, The Hospital for Sick Children, University of Toronto, ON, Canada, ou_persistent22              

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Free keywords: Brain imaging; Depression; Dopamine; Parkinson's disease; Positron emission tomography; 5-HT
 Abstract: Monoamine oxidase A (MAO-A) is an important target in the pathophysiology and therapeutics of major depressive disorder, aggression, and neurodegenerative conditions. We measured the effect of changes in MAO-A substrate on MAO-A binding in regions implicated in affective and neurodegenerative disease with [11C]-harmine positron emission tomography in healthy volunteers. Monoamine oxidase A VT, an index of MAO-A density, was decreased (mean: 14%±9%) following tryptophan depletion in prefrontal cortex (P<0.031), and elevated (mean: 17%±11%) in striatum following carbidopa–levodopa administration (P<0.007). These findings suggest an adaptive role for MAO-A in maintaining monoamine neurotransmitter homeostasis by rapidly compensating fluctuating monoamine levels.

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Language(s): eng - English
 Dates: 2011-09-012011-05-202011-10-142011-12-212012-03
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1038/jcbfm.2011.184
PMID: 22186668
PMC: PMC3293124
Other: Epub 2011
 Degree: -

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Title: Journal of Cerebral Blood Flow and Metabolism
Source Genre: Journal
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Publ. Info: New York : Lippincott Williams & Wilkins
Pages: - Volume / Issue: 32 (3) Sequence Number: - Start / End Page: 443 - 446 Identifier: ISSN: 0271-678X
CoNE: https://pure.mpg.de/cone/journals/resource/954925503202