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  Prefrontal-parietal effective connectivity during working memory in older adults

Heinzel, S., Lorenz, R. C., Duong, Q.-L., Rapp, M. A., & Deserno, L. (2017). Prefrontal-parietal effective connectivity during working memory in older adults. Neurobiology of Aging, 57, 18-27. doi:10.1016/j.neurobiolaging.2017.05.005.

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Datensatz-Permalink: https://hdl.handle.net/11858/00-001M-0000-002E-08FC-4 Versions-Permalink: https://hdl.handle.net/21.11116/0000-0003-C623-6
Genre: Zeitschriftenartikel

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Urheber

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 Urheber:
Heinzel, Stephan1, 2, 3, Autor
Lorenz, Robert C.4, 5, Autor
Duong, Quynh-Lam4, Autor
Rapp, Michael A. 2, 6, Autor
Deserno, Lorenz7, 8, Autor           
Affiliations:
1Department of Psychology, FU Berlin, Germany, ou_persistent22              
2Department of Social and Preventive Medicine, University of Potsdam, Germany, ou_persistent22              
3Department of Psychology, Humboldt University Berlin, Germany, ou_persistent22              
4Department of Psychiatry and Psychotherapy, Charité University Medicine Berlin, Germany, ou_persistent22              
5Max Planck Institute for Human Development, Berlin, Germany, ou_persistent22              
6NeuroCure Cluster of Excellence, Charité University Medicine Berlin, Germany, ou_persistent22              
7Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, Leipzig, DE, ou_634549              
8Department of Child and Adolescent Psychiatry, Psychotherapy, and Psychosomatics, University of Leipzig, Germany, ou_persistent22              

Inhalt

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Schlagwörter: Aging; Dynamic causal modeling (DCM); Effective connectivity; Functional magnetic resonance imaging (fMRI); Working memory
 Zusammenfassung: Theoretical models and preceding studies have described age-related alterations in neuronal activation of frontoparietal regions in a working memory (WM) load-dependent manner. However, to date, underlying neuronal mechanisms of these WM load-dependent activation changes in aging remain poorly understood. The aim of this study was to investigate these mechanisms in terms of effective connectivity by application of dynamic causal modeling with Bayesian Model Selection. Eighteen healthy younger (age: 20–32 years) and 32 older (60–75 years) participants performed an n-back task with 3 WM load levels during functional magnetic resonance imaging (fMRI). Behavioral and conventional fMRI results replicated age group by WM load interactions. Importantly, the analysis of effective connectivity derived from dynamic causal modeling, indicated an age- and performance-related reduction in WM load-dependent modulation of connectivity from dorsolateral prefrontal cortex to inferior parietal lobule. This finding provides evidence for the proposal that age-related WM decline manifests as deficient WM load-dependent modulation of neuronal top-down control and can integrate implications from theoretical models and previous studies of functional changes in the aging brain.

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Sprache(n): eng - English
 Datum: 2017-03-242016-08-292017-05-022017-05-102017-09
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: DOI: 10.1016/j.neurobiolaging.2017.05.005
PMID: 28578155
Anderer: Epub 2017
 Art des Abschluß: -

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Projektinformation

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Projektname : -
Grant ID : -
Förderprogramm : -
Förderorganisation : Studienstiftung des Deutschen Volkes
Projektname : -
Grant ID : 01QG87164 ; 01GS08195 ; 01GQ0914
Förderprogramm : -
Förderorganisation : German Ministry for Education and Research (BMBF)
Projektname : Lern- und Gewöhnungsprozesse als Prädiktoren für die Entwicklung und Aufrechterhaltung alkoholbezogener Störungen / FOR 1617
Grant ID : RA 1047/2-1
Förderprogramm : -
Förderorganisation : German Research Foundation (DFG)
Projektname : Human performance under multiple cognitive task requirements: From basic mechanisms to optimized task scheduling / SPP 1772
Grant ID : RA 1047/4-1 ; HE 7464/1-1
Förderprogramm : -
Förderorganisation : German Research Foundation (DFG)
Projektname : -
Grant ID : -
Förderprogramm : -
Förderorganisation : Max-Planck International Research Network on Aging (MaxNetAging)
Projektname : -
Grant ID : -
Förderprogramm : -
Förderorganisation : Max Planck Society

Quelle 1

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Titel: Neurobiology of Aging
  Andere : Neurobiol. Aging
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: New York, NY [etc.] : Elsevier
Seiten: - Band / Heft: 57 Artikelnummer: - Start- / Endseite: 18 - 27 Identifikator: ISSN: 0197-4580
CoNE: https://pure.mpg.de/cone/journals/resource/954925491902