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  Hexadecylphosphocholine, a new ether lipid analogue. Studies on the antineoplastic activity in vitro and in vivo.

Unger, C., Damenz, W., Fleer, E., Kim, D. J., Breiser, A., Hilgard, P., et al. (1989). Hexadecylphosphocholine, a new ether lipid analogue. Studies on the antineoplastic activity in vitro and in vivo. Acta Oncologica, 28(22), 213-217. doi:10.3109/02841868909111249.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-002C-915A-C Version Permalink: https://hdl.handle.net/11858/00-001M-0000-002C-915B-A
Genre: Journal Article

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2404140.pdf (Publisher version), 567KB
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 Creators:
Unger, C., Author
Damenz, W., Author
Fleer, E.1, Author           
Kim, D. J., Author
Breiser, A., Author
Hilgard, P., Author
Engel, J., Author
Nagel, G., Author
Eibl, H. J.1, Author           
Affiliations:
1Department of Membrane Biophysics, MPI for biophysical chemistry, Max Planck Society, ou_578579              

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 Abstract: Hexadecylphosphocholine (He-PC) is a new compound synthesized according to the minimal structural requirements deducted from studies with other ether lipids. In vitro studies on He-PC revealed remarkable antineoplastic activity on HL60, U937, Raji and K562 leukemia cell lines. In addition, He-PC, applied orally, showed a superior effect in the treatment of dimethylbenzanthracene-induced rat mammary carcinomas when compared to intravenously administered cyclophosphamide. After oral application He-PC was well absorbed from the intestine and metabolized in the liver by phospholipases C and D. During a 5-week treatment no hematotoxic effects were detected. In a clinical pilot study on breast cancer patients with widespread skin involvement, topically applied He-PC showed skin tumor regressions without local or systemic side effects.

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Language(s): eng - English
 Dates: 1989
 Publication Status: Issued
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 Rev. Type: Peer
 Identifiers: DOI: 10.3109/02841868909111249
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Title: Acta Oncologica
Source Genre: Journal
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Pages: - Volume / Issue: 28 (22) Sequence Number: - Start / End Page: 213 - 217 Identifier: -