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Purpose To develop and test a novel method for the coil placement in interleaved Transcranial Magnetic Stimulation(TMS)/fMRI studies.
Materials and Methods Initially, a desired TMS coil position at the subjects head is recorded using a neuronavigation system. Subsequently, a custom-made holding device is used for coil placement inside the MR scanner. The parameters of the device corresponding to the prerecorded position are automatically determined from a fast structural image acquired directly before the experiment. The spatial accuracy of our method was verified on a phantom. Finally, in a study on 5 subjects, the coil was placed above the cortical representation of a hand muscle in M1 and the BOLD responses to short rTMS trains were assessed using EPI recordings.
Results The spatial accuracy of our method is in the range of 2.9±1.3(SD) mm. Motor cortex stimulation resulted in robust BOLD activations in motor- and auditory-related brain areas, with the activation in M1 being localized in the hand knob.
Conclusion We present a user-friendly method for TMS coil positioning in the MR scanner that exhibits good spatial accuracy and speeds up the setup of the experiment. The motor-cortex study proves the viability of the approach and validates our interleaved TMS/fMRI setup.
