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  Association of estradiol and visceral fat with structural brain networks and memory performance in adults

Zsido, R., Heinrich, M., Slavich, G. M., Beyer, F., Kharabian, S., Kratzsch, J., et al. (2019). Association of estradiol and visceral fat with structural brain networks and memory performance in adults. JAMA Network Open, 2(6): e196126. doi:10.1001/jamanetworkopen.2019.6126.

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Item Permalink: https://hdl.handle.net/21.11116/0000-0003-F9A7-8 Version Permalink: https://hdl.handle.net/21.11116/0000-0005-0EF5-8
Genre: Journal Article

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 Creators:
Zsido, Rachel1, 2, Author           
Heinrich, Matthias1, 2, Author           
Slavich, George M.3, Author
Beyer, Frauke1, 4, Author           
Kharabian, Shahrzad1, Author           
Kratzsch, Jürgen5, Author
Raschpichler, Matthias6, 7, Author
Mueller, Karsten8, Author           
Scharrer, Ulrike1, 2, 9, Author
Löffler, Markus10, 11, Author
Schroeter, Matthias L.1, 9, 11, Author           
Stumvoll, Michael4, 7, Author
Villringer, Arno1, 9, 11, Author           
Witte, A. Veronica1, 4, Author           
Sacher, Julia1, 2, 9, Author           
Affiliations:
1Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
2Emotion Neuroimaging Lab, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_persistent22              
3Cousins Center for Psychoneuroimmunology, Department of Psychiatry, University of California, Los Angeles, CA, USA, ou_persistent22              
4Collaborative Research Center Obesity Mechanisms, Institute of Biochemistry, University of Leipzig, Germany, ou_persistent22              
5Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics (ILM), University of Leipzig, Germany, ou_persistent22              
6Heart Center, Helios Hospital, University of Leipzig, Germany, ou_persistent22              
7Integrated Research and Treatment Center Adiposity Diseases, University of Leipzig, Germany, ou_persistent22              
8Methods and Development Unit Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634558              
9Clinic for Cognitive Neurology, University of Leipzig, Germany, ou_persistent22              
10Institute for Medical Informatics, Statistics and Epidemiology (IMISE), University of Leipzig, Germany, ou_persistent22              
11Leipzig Research Center for Civilization Diseases (LIFE), University of Leipzig, Germany, ou_persistent22              

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 Abstract: Importance Changes in estradiol during aging are associated with increased dementia risk. It remains unclear how estradiol supports cognitive health and whether risk factors, such as midlife obesity, are exacerbated by estrogen loss.

Objectives To assess whether visceral adipose tissue (VAT) moderates the association between age and brain network structure and to investigate whether estradiol moderates the association between VAT and brain network structure.

Design, Setting, and Participants Cross-sectional study of data from 974 cognitively healthy adults in Germany who participated in the Health Study of the Leipzig Research Centre for Civilization Diseases, a previously described population-based cohort study. Two moderation analyses were performed, including VAT as the moderator variable between age and brain network structure and estradiol as the moderator variable between VAT and brain network structure. The study was conducted from August 1, 2011, to November 23, 2014. Analyses were conducted from August 2017 to September 2018

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Language(s): eng - English
 Dates: 2019-05-032019-06-21
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1001/jamanetworkopen.2019.6126
PMID: 31225892
PMC: PMC6593958
 Degree: -

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Project name : -
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Funding program : The Branco Weiss Fellowship – Society in Science
Funding organization : ETH Zurich
Project name : -
Grant ID : 25032
Funding program : Young Investigator Grant
Funding organization : Brain & Behavior Research Foundation
Project name : -
Grant ID : 713-241202 ; 14505/2470 ; 14575/2470
Funding program : -
Funding organization : LIFE – Leipzig Research Center for Civilization Diseases, University of Leipzig
Project name : -
Grant ID : -
Funding program : -
Funding organization : European Union (EU)
Project name : -
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Funding program : European Regional Development Fund
Funding organization : European Commission (EC)
Project name : -
Grant ID : -
Funding program : -
Funding organization : Free State of Saxony
Project name : -
Grant ID : -
Funding program : Minerva Research Group Grant
Funding organization : Max Planck Society
Project name : Obesity Mechanisms / SFB 1052
Grant ID : -
Funding program : -
Funding organization : Deutsche Forschungsgemeinschaft (DFG)

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Title: JAMA Network Open
Source Genre: Journal
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Publ. Info: Chicago, IL : American Medical Association
Pages: - Volume / Issue: 2 (6) Sequence Number: e196126 Start / End Page: - Identifier: ISSN: 2574-3805
CoNE: https://pure.mpg.de/cone/journals/resource/2574-3805