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  Disentangling the neural correlates of corticobasal syndrome and corticobasal degeneration with systematic and quantitative ALE meta-analyses

Albrecht, F., Bisenius, S., Schaack, R. M., Neumann, J., & Schroeter, M. L. (2017). Disentangling the neural correlates of corticobasal syndrome and corticobasal degeneration with systematic and quantitative ALE meta-analyses. npj Parkinson's Disease, 3: 12. doi:10.1038/s41531-017-0012-6.

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Datensatz-Permalink: https://hdl.handle.net/11858/00-001M-0000-002C-ECFC-7 Versions-Permalink: https://hdl.handle.net/21.11116/0000-0003-BA82-8
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 Urheber:
Albrecht, Franziska1, Autor           
Bisenius, Sandrine1, Autor           
Schaack, Rodrigo Morales1, Autor
Neumann, Jane1, 2, Autor           
Schroeter, Matthias L.1, 3, Autor           
Affiliations:
1Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
2Integrated Research and Treatment Center Adiposity Diseases, University of Leipzig, Germany, ou_persistent22              
3Clinic for Cognitive Neurology, University of Leipzig, Germany, ou_persistent22              

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 Zusammenfassung: Corticobasal degeneration is a scarce neurodegenerative disease, which can only be confirmed by histopathological examination. Reported to be associated with various clinical syndromes, its classical clinical phenotype is corticobasal syndrome. Due to the rareness of corticobasal syndrome/corticobasal degeneration and low numbers of patients included in single studies, meta-analyses are particularly suited to disentangle features of the clinical syndrome and histopathology. Using PubMed, we identified 11 magnetic resonance imaging studies measuring atrophy in 22 independent cohorts with 200 patients contrasted to 318 healthy controls. The anatomic likelihood estimation method was applied to reveal affected brain regions across studies. Corticobasal syndrome was related to gray matter loss in the basal ganglia/thalamus, frontal, parietal, and temporal lobes. In corticobasal degeneration patients, atrophy in the thalamus, frontal, temporal, and occipital lobes were found. Finally, in a conjunction analysis, the bilateral thalamus, the bilateral posterior frontomedian cortex, posterior midcingulate cortex and premotor area/supplementary motor area, and the left posterior superior and middle frontal gyrus/precentral gyrus were identified as areas associated with both, corticobasal syndrome and corticobasal degeneration. Remarkably, atrophy in the premotor area/supplementary motor area and posterior midcingulate/frontomedian cortex seems to be specific for corticobasal syndrome/corticobasal degeneration, whereas atrophy in the thalamus and the left posterior superior and middle frontal gyrus/precentral gyrus are also associated with other neurodegenerative diseases according to anatomic likelihood estimation method meta-analyses. Our study creates a new conceptual framework to understand, and distinguish between clinical features (corticobasal syndrome) and histopathological findings (corticobasal degeneration) by powerful data-driven meta-analytic approaches. Furthermore, it proposes regional-specific atrophy as an imaging biomarker for diagnosis of corticobasal syndrome/corticobasal degeneration ante-mortem.

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Sprache(n): eng - English
 Datum: 2016-12-092016-02-032017-01-182017-03-31
 Publikationsstatus: Online veröffentlicht
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: DOI: 10.1038/s41531-017-0012-6
PMID: 28649612
PMC: PMC5459811
Anderer: eCollection 2017
 Art des Abschluß: -

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Projektname : -
Grant ID : -
Förderprogramm : -
Förderorganisation : Max-Planck International Research Network on Aging (MaxNetAging)
Projektname : -
Grant ID : -
Förderprogramm : -
Förderorganisation : IFB Adiposity Diseases, German Federal Ministry of Education and Research (BMBF)
Projektname : Obesity Mechanisms / SFB 1052
Grant ID : -
Förderprogramm : -
Förderorganisation : German Research Foundation (DFG)
Projektname : German Consortium for Frontotemporal Lobar Degeneration
Grant ID : 01GI1007A
Förderprogramm : -
Förderorganisation : German Federal Ministry of Education and Research (BMBF)
Projektname : -
Grant ID : PDF-IRG-1307
Förderprogramm : -
Förderorganisation : Parkinson’s Disease Foundation
Projektname : -
Grant ID : MJFF-11362
Förderprogramm : -
Förderorganisation : Michael J Fox Foundation
Projektname : -
Grant ID : -
Förderprogramm : -
Förderorganisation : LIFE – Leipzig Research Center for Civilization Diseases at the University of Leipzig
Projektname : -
Grant ID : -
Förderprogramm : -
Förderorganisation : European Union (EU)
Projektname : -
Grant ID : -
Förderprogramm : European Regional Development Fund
Förderorganisation : European Commission (EC)
Projektname : -
Grant ID : -
Förderprogramm : -
Förderorganisation : Free State of Saxony

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Titel: npj Parkinson's Disease
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: London : Nature Publ. Group
Seiten: - Band / Heft: 3 Artikelnummer: 12 Start- / Endseite: - Identifikator: ISSN: 2373-8057
CoNE: https://pure.mpg.de/cone/journals/resource/2373-8057