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  Parasitic behavior in competing chemically fueled reaction cycles

Schwarz, P. S., Laha, S., Janssen, J., Huss, T., Boekhoven, J., & Weber, C. A. (2021). Parasitic behavior in competing chemically fueled reaction cycles. Chemical Science. doi:10.1039/d1sc01106e.

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 Creators:
Schwarz, Patrick S.1, Author
Laha, Sudarshana1, Author
Janssen, Jacqueline1, Author
Huss, Tabea1, Author
Boekhoven, Job1, Author
Weber, Christoph A.2, Author              
Affiliations:
1external, ou_persistent22              
2Max Planck Institute for the Physics of Complex Systems, Max Planck Society, ou_2117288              

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 Abstract: Non-equilibrium, fuel-driven reaction cycles serve as model systems of the intricate reaction networks of life. Rich and dynamic behavior is observed when reaction cycles regulate assembly processes, such as phase separation. However, it remains unclear how the interplay between multiple reaction cycles affects the success of emergent assemblies. To tackle this question, we created a library of molecules that compete for a common fuel that transiently activates products. Often, the competition for fuel implies that a competitor decreases the lifetime of these products. However, in cases where the transient competitor product can phase-separate, such a competitor can increase the survival time of one product. Moreover, in the presence of oscillatory fueling, the same mechanism reduces variations in the product concentration while the concentration variations of the competitor product are enhanced. Like a parasite, the product benefits from the protection of the host against deactivation and increases its robustness against fuel variations at the expense of the robustness of the host. Such a parasitic behavior in multiple fuel-driven reaction cycles represents a lifelike trait, paving the way for the bottom-up design of synthetic life.

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 Dates: 2021-04-282021-07-06
 Publication Status: Published in print
 Pages: -
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 Rev. Type: -
 Identifiers: ISI: 000646785900001
DOI: 10.1039/d1sc01106e
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Title: Chemical Science
  Other : Chem. Sci.
Source Genre: Journal
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Publ. Info: Cambridge, UK : Royal Society of Chemistry
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: - Identifier: ISSN: 2041-6520
CoNE: https://pure.mpg.de/cone/journals/resource/2041-6520