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Free keywords:
disulfonimides; kinetics; Mukaiyama aldol reaction; organocatalysis; reaction progress kinetic analysis
Abstract:
Making progress: The kinetics of the disulfonimide-catalyzed Mukaiyama aldol reaction have been established by using the reaction progress kinetic analysis (RPKA) method. The reaction is first order with respect to catalyst and silyl ketene acetal, and has an order of 0.55 with respect to the aldehyde, which suggests the reversibility of the binding between the aldehyde and the actual catalyst.
