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  Whole-brain neuronal activity displays crackling noise dynamics

Ponce-Alvarez, A., Jouary, A., Privat, M., Deco, G., & Sumbre, G. (2018). Whole-brain neuronal activity displays crackling noise dynamics. Neuron, 100(6): e6, pp. 1446-1459. doi:10.1016/j.neuron.2018.10.045.

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Item Permalink: https://hdl.handle.net/21.11116/0000-0002-B8B6-1 Version Permalink: https://hdl.handle.net/21.11116/0000-0003-9FD7-8
Genre: Journal Article

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 Creators:
Ponce-Alvarez, Adrián1, Author
Jouary, Adrien2, 3, Author
Privat, Martin2, Author
Deco, Gustavo1, 4, 5, 6, Author           
Sumbre, Germán2, Author
Affiliations:
1Department of Information and Communication Technologies, Center for Brain and Cognition, University Pompeu Fabra, Barcelona, Spain, ou_persistent22              
2Institut de biologie de l’Ecole normale supérieure (IBENS), Ecole normale supérieure, Paris, France, ou_persistent22              
3Champalimaud Research, Champalimaud Centre for the Unknown, Lisbon, Portugal, ou_persistent22              
4Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634551              
5Catalan Institution for Research and Advanced Studies (ICREA), University Pompeu Fabra, Barcelona, Spain, ou_persistent22              
6School of Psychological Sciences, Monash University, Melbourne, Australia, ou_persistent22              

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Free keywords: Phase transitions; Scale invariance; Whole-brain dynamics; Calcium; Imaging; Zebrafish; GcaMP; Light-sheet microscopy; Gap junctions; Sensory modulation motor behavior
 Abstract: Previous studies suggest that the brain operates at a critical point in which phases of order and disorder coexist, producing emergent patterned dynamics at all scales and optimizing several brain functions. Here, we combined light-sheet microscopy with GCaMP zebrafish larvae to study whole-brain dynamics in vivo at near single-cell resolution. We show that spontaneous activity propagates in the brain’s three-dimensional space, generating scale-invariant neuronal avalanches with time courses and recurrence times that exhibit statistical self-similarity at different magnitude, temporal, and frequency scales. This suggests that the nervous system operates close to a non-equilibrium phase transition, where a large repertoire of spatial, temporal, and interactive modes can be supported. Finally, we show that gap junctions contribute to the maintenance of criticality and that, during interactions with the environment (sensory inputs and self-generated behaviors), the system is transiently displaced to a more ordered regime, conceivably to limit the potential sensory representations and motor outcomes.

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Language(s): eng - English
 Dates: 2018-07-052018-01-092018-10-242018-11-162018-12-19
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1016/j.neuron.2018.10.045
PMID: 30449656
PMC: PMC6307982
Other: Epub 2018
 Degree: -

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Project name : -
Grant ID : IJCI-2014-21066
Funding program : Juan de la Cierva fellowship
Funding organization : Spanish Ministry of Economy and Competitiveness
Project name : -
Grant ID : FDT20140930915
Funding program : -
Funding organization : Fondation pour la Recherche Medicale
Project name : -
Grant ID : -
Funding program : -
Funding organization : École normale supérieure de Cachan (ENS Cachan)
Project name : -
Grant ID : -
Funding program : -
Funding organization : École normale supérieure de Lyon (ENS Lyon)
Project name : The Dynamical and Structural Basis of Human Mind Complexity: Segregation and Integration of Information and Processing in the Brain / DYSTRUCTURE
Grant ID : 295129
Funding program : Funding Programme 7
Funding organization : European Commission (EC)
Project name : Spanish National Project Complexity of Brain States
Grant ID : PSI2016-75688-P
Funding program : -
Funding organization : Spanish Research Agency (AEI) and the European Regional Development Fund (ERDF)
Project name : Human Brain Project Specific Grant Agreement 1 / HBP SGA1
Grant ID : 720270
Funding program : Horizon 2020
Funding organization : European Commission (EC)
Project name : Sensory perception: neural representation and modulation / ZEBRAFISH PERCEPTION
Grant ID : 243106
Funding program : Funding Programme 7
Funding organization : European Commission (EC)
Project name : Whole-brain dynamics underlying self-generated behaviour / Spontaneous ZeBrain
Grant ID : 726280
Funding program : Horizon 2020
Funding organization : European Commission (EC)
Project name : -
Grant ID : ANR-10-LABX-54 MEMO LIFE ; ANR-11-IDEX-0001-02
Funding program : -
Funding organization : PSL Research University

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Title: Neuron
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Cambridge, Mass. : Cell Press
Pages: - Volume / Issue: 100 (6) Sequence Number: e6 Start / End Page: 1446 - 1459 Identifier: ISSN: 0896-6273
CoNE: https://pure.mpg.de/cone/journals/resource/954925560565