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  Shared genetic risk between eating disorder- and substance-use-related phenotypes: Evidence from genome-wide association studies

Munn-Chernoff, M. A., Johnson, E. C., Chou, Y.-L., Coleman, J. R. I., Thornton, L. M., Walters, R. K., et al. (2021). Shared genetic risk between eating disorder- and substance-use-related phenotypes: Evidence from genome-wide association studies. ADDICTION BIOLOGY, 26(1): e12880. doi:10.1111/adb.12880.

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Munn-Chernoff, Melissa A., Author
Johnson, Emma C., Author
Chou, Yi-Ling, Author
Coleman, Jonathan R. I., Author
Thornton, Laura M., Author
Walters, Raymond K., Author
Yilmaz, Zeynep, Author
Baker, Jessica H., Author
Hubel, Christopher, Author
Gordon, Scott, Author
Medland, Sarah E., Author
Watson, Hunna J., Author
Gaspar, Helena A., Author
Bryois, Julien, Author
Hinney, Anke, Author
Leppa, Virpi M., Author
Mattheisen, Manuel, Author
Ripke, Stephan, Author
Yao, Shuyang, Author
Giusti-Rodriguez, Paola, Author
Hanscombe, Ken B., AuthorAdan, Roger A. H., AuthorAlfredsson, Lars, AuthorAndo, Tetsuya, AuthorAndreassen, Ole A., AuthorBerrettini, Wade H., AuthorBoehm, Ilka, AuthorBoni, Claudette, AuthorBoraska Perica, Vesna, AuthorBuehren, Katharina, AuthorBurghardt, Roland, AuthorCassina, Matteo, AuthorCichon, Sven, AuthorClementi, Maurizio, AuthorCone, Roger D., AuthorCourtet, Philippe, AuthorCrow, Scott, AuthorCrowley, James J., AuthorDanner, Unna N., AuthorDavis, Oliver S. P., Authorde Zwaan, Martina, AuthorDedoussis, George, AuthorDegortes, Daniela, AuthorDeSocio, Janiece E., AuthorDick, Danielle M., AuthorDikeos, Dimitris, AuthorDina, Christian, AuthorDmitrzak-Weglarz, Monika, AuthorDocampo, Elisa, AuthorDuncan, Laramie E., AuthorEgberts, Karin, AuthorEhrlich, Stefan, AuthorEscaramis, Georgia, AuthorEsko, Tonu, AuthorEstivill, Xavier, AuthorFarmer, Anne, AuthorFavaro, Angela, AuthorFernandez-Aranda, Fernando, AuthorFichter, Manfred M., AuthorFischer, Krista, AuthorFoecker, Manuel, AuthorForetova, Lenka, AuthorForstner, Andreas J., AuthorForzan, Monica, AuthorFranklin, Christopher S., AuthorGallinger, Steven, AuthorGiegling, Ina, AuthorGiuranna, Johanna, AuthorGonidakis, Fragiskos, AuthorGorwood, Philip, AuthorGratacos Mayora, Monica, AuthorGuillaume, Sebastien, AuthorGuo, Yiran, AuthorHakonarson, Hakon, AuthorHatzikotoulas, Konstantinos, AuthorHauser, Joanna, AuthorHebebrand, Johannes, AuthorHelder, Sietske G., AuthorHerms, Stefan, AuthorHerpertz-Dahlmann, Beate, AuthorHerzog, Wolfgang, AuthorHuckins, Laura M., AuthorHudson, James I., AuthorImgart, Hartmut, AuthorInoko, Hidetoshi, AuthorJanout, Vladimir, AuthorJimenez-Murcia, Susana, AuthorJulia, Antonio, AuthorKalsi, Gursharan, AuthorKaminska, Deborah, AuthorKarhunen, Leila, AuthorKarwautz, Andreas, AuthorKas, Martien J. H., AuthorKennedy, James L., AuthorKeski-Rahkonen, Anna, AuthorKiezebrink, Kirsty, AuthorKim, Youl-Ri, AuthorKlump, Kelly L., AuthorKnudsen, Gun Peggy S., AuthorLa Via, Maria C., AuthorLe Hellard, Stephanie, AuthorLevitan, Robert D., AuthorLi, Dong, AuthorLilenfeld, Lisa, AuthorLin, Bochao Danae, AuthorLissowska, Jolanta, AuthorLuykx, Jurjen, AuthorMagistretti, Pierre J., AuthorMaj, Mario, AuthorMannik, Katrin, AuthorMarsal, Sara, AuthorMarshall, Christian R., AuthorMattingsdal, Morten, AuthorMcDevitt, Sara, AuthorMcGuffin, Peter, AuthorMetspalu, Andres, AuthorMeulenbelt, Ingrid, AuthorMicali, Nadia, AuthorMitchell, Karen, AuthorMonteleone, Alessio Maria, AuthorMonteleone, Palmiero, AuthorNacmias, Benedetta, AuthorNavratilova, Marie, AuthorNtalla, Ioanna, AuthorO'Toole, Julie K., AuthorOphoff, Roel A., AuthorPadyukov, Leonid, AuthorPalotie, Aarno, AuthorPantel, Jacques, AuthorPapezova, Hana, AuthorPinto, Dalila, AuthorRabionet, Raquel, AuthorRaevuori, Anu, AuthorRamoz, Nicolas, AuthorReichborn-Kjennerud, Ted, AuthorRicca, Valdo, AuthorRipatti, Samuli, AuthorRitschel, Franziska, AuthorRoberts, Marion, AuthorRotondo, Alessandro, AuthorRujescu, Dan, AuthorRybakowski, Filip, AuthorSantonastaso, Paolo, AuthorScherag, Andre, AuthorScherer, Stephen W., AuthorSchmidt, Ulrike, AuthorSchork, Nicholas J., AuthorSchosser, Alexandra, AuthorSeitz, Jochen, AuthorSlachtova, Lenka, AuthorSlagboom, P. Eline, AuthorSlof-Op't Landt, Margarita C. T., AuthorSlopien, Agnieszka, AuthorSorbi, Sandro, AuthorSwiatkowska, Beata, AuthorSzatkiewicz, Jin P., AuthorTachmazidou, Ioanna, AuthorTenconi, Elena, AuthorTortorella, Alfonso, AuthorTozzi, Federica, AuthorTreasure, Janet, AuthorTsitsika, Artemis, AuthorTyszkiewicz-Nwafor, Marta, AuthorTziouvas, Konstantinos, Authorvan Elburg, Annemarie A., Authorvan Furth, Eric F., AuthorWagner, Gudrun, AuthorWalton, Esther, AuthorWiden, Elisabeth, AuthorZeggini, Eleftheria, AuthorZerwas, Stephanie, AuthorZipfel, Stephan, AuthorBergen, Andrew W., AuthorBoden, Joseph M., AuthorBrandt, Harry, AuthorCrawford, Steven, AuthorHalmi, Katherine A., AuthorHorwood, L. John, AuthorJohnson, Craig, AuthorKaplan, Allan S., AuthorKaye, Walter H., AuthorMitchell, James, AuthorOlsen, Catherine M., AuthorPearson, John F., AuthorPedersen, Nancy L., AuthorStrober, Michael, AuthorWerge, Thomas, AuthorWhiteman, David C., AuthorWoodside, D. Blake, AuthorGrove, Jakob, AuthorHenders, Anjali K., AuthorLarsen, Janne T., AuthorParker, Richard, AuthorPetersen, Liselotte V., AuthorJordan, Jennifer, AuthorKennedy, Martin A., AuthorBirgegard, Andreas, AuthorLichtenstein, Paul, AuthorNorring, Claes, AuthorLanden, Mikael, AuthorMortensen, Preben Bo, AuthorPolimanti, Renato, AuthorMcClintick, Jeanette N., AuthorAdkins, Amy E., AuthorAliev, Fazil, AuthorBacanu, Silviu-Alin, AuthorBatzler, Anthony, AuthorBertelsen, Sarah, AuthorBiernacka, Joanna M., AuthorBigdeli, Tim B., AuthorChen, Li-Shiun, AuthorClarke, Toni-Kim, AuthorDegenhardt, Franziska, AuthorDocherty, Anna R., AuthorEdwards, Alexis C., AuthorFoo, Jerome C., AuthorFox, Louis, AuthorFrank, Josef, AuthorHack, Laura M., AuthorHartmann, Annette M., AuthorHartz, Sarah M., AuthorHeilmann-Heimbach, Stefanie, AuthorHodgkinson, Colin, AuthorHoffmann, Per, AuthorHottenga, Jouke-Jan, AuthorKonte, Bettina, AuthorLahti, Jari, AuthorLahti-Pulkkinen, Marius, AuthorLai, Dongbing, AuthorLigthart, Lannie, AuthorLoukola, Anu, AuthorMaher, Brion S., AuthorMbarek, Hamdi, AuthorMcIntosh, Andrew M., AuthorMcQueen, Matthew B., AuthorMeyers, Jacquelyn L., AuthorMilaneschi, Yuri, AuthorPalviainen, Teemu, AuthorPeterson, Roseann E., AuthorRyu, Euijung, AuthorSaccone, Nancy L., AuthorSalvatore, Jessica E., AuthorSanchez-Roige, Sandra, AuthorSchwandt, Melanie, AuthorSherva, Richard, AuthorStreit, Fabian, AuthorStrohmaier, Jana, AuthorThomas, Nathaniel, AuthorWang, Jen-Chyong, AuthorWebb, Bradley T., AuthorWedow, Robbee, AuthorWetherill, Leah, AuthorWills, Amanda G., AuthorZhou, Hang, AuthorBoardman, Jason D., AuthorChen, Danfeng, AuthorChoi, Doo-Sup, AuthorCopeland, William E., AuthorCulverhouse, Robert C., AuthorDahmen, Norbert, AuthorDegenhardt, Louisa, AuthorDomingue, Benjamin W., AuthorFrye, Mark A., AuthorGabel, Wolfgang, AuthorHayward, Caroline, AuthorIsing, Marcus1, Author           Keyes, Margaret, AuthorKiefer, Falk, AuthorKoller, Gabriele, AuthorKramer, John, AuthorKuperman, Samuel, AuthorLucae, Susanne1, Author           Lynskey, Michael T., AuthorMaier, Wolfgang, AuthorMann, Karl, AuthorMaennistoe, Satu, AuthorMueller-Myhsok, Bertram2, Author           Murray, Alison D., AuthorNurnberger, John I., AuthorPreuss, Ulrich, AuthorRaikkonen, Katri, AuthorReynolds, Maureen D., AuthorRidinger, Monika, AuthorScherbaum, Norbert, AuthorSchuckit, Marc A., AuthorSoyka, Michael, AuthorTreutlein, Jens, AuthorWitt, Stephanie H., AuthorWodarz, Norbert, AuthorZill, Peter, AuthorAdkins, Daniel E., AuthorBoomsma, Dorret I., AuthorBierut, Laura J., AuthorBrown, Sandra A., AuthorBucholz, Kathleen K., AuthorCostello, E. Jane, AuthorDe Wit, Harriet, AuthorDiazgranados, Nancy, AuthorEriksson, Johan G., AuthorFarrer, Lindsay A., AuthorForoud, Tatiana M., AuthorGillespie, Nathan A., AuthorGoate, Alison M., AuthorGoldman, David, AuthorGrucza, Richard A., AuthorHancock, Dana B., AuthorHarris, Kathleen Mullan, AuthorHesselbrock, Victor, AuthorHewitt, John K., AuthorHopfer, Christian J., AuthorIacono, William G., AuthorJohnson, Eric O., AuthorKarpyak, Victor M., AuthorKendler, Kenneth S., AuthorKranzler, Henry R., AuthorKrauter, Kenneth, AuthorLind, Penelope A., AuthorMcGue, Matt, AuthorMacKillop, James, AuthorMadden, Pamela A. F., AuthorMaes, Hermine H., AuthorMagnusson, Patrik K. E., AuthorNelson, Elliot C., AuthorNoethen, Markus M., AuthorPalmer, Abraham A., AuthorPenninx, Brenda W. J. H., AuthorPorjesz, Bernice, AuthorRice, John P., AuthorRietschel, Marcella, AuthorRiley, Brien P., AuthorRose, Richard J., AuthorShen, Pei-Hong, AuthorSilberg, Judy, AuthorStallings, Michael C., AuthorTarter, Ralph E., AuthorVanyukov, Michael M., AuthorVrieze, Scott, AuthorWall, Tamara L., AuthorWhitfield, John B., AuthorZhao, Hongyu, AuthorNeale, Benjamin M., AuthorWade, Tracey D., AuthorHeath, Andrew C., AuthorMontgomery, Grant W., AuthorMartin, Nicholas G., AuthorSullivan, Patrick F., AuthorKaprio, Jaakko, AuthorBreen, Gerome, AuthorGelernter, Joel, AuthorEdenberg, Howard J., AuthorBulik, Cynthia M., AuthorAgrawal, Arpana, Author more..
Affiliations:
1Max Planck Institute of Psychiatry, Max Planck Society, ou_1607137              
2RG Statistical Genetics, Max Planck Institute of Psychiatry, Max Planck Society, ou_2040288              

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Free keywords: ALCOHOL DEPENDENCE; ANOREXIA-NERVOSA; DRUG-USE; ENVIRONMENTAL CONTRIBUTIONS; BULIMIA-NERVOSA; WOMEN; GWAS; TWIN; ENDOCANNABINOIDS; COMORBIDITYBiochemistry & Molecular Biology; Substance Abuse; eating disorders; genetic correlation; substance use;
 Abstract: Eating disorders and substance use disorders frequently co-occur. Twin studies reveal shared genetic variance between liabilities to eating disorders and substance use, with the strongest associations between symptoms of bulimia nervosa and problem alcohol use (genetic correlation [r(g)], twin-based = 0.23-0.53). We estimated the genetic correlation between eating disorder and substance use and disorder phenotypes using data from genome-wide association studies (GWAS). Four eating disorder phenotypes (anorexia nervosa [AN], AN with binge eating, AN without binge eating, and a bulimia nervosa factor score), and eight substance-use-related phenotypes (drinks per week, alcohol use disorder [AUD], smoking initiation, current smoking, cigarettes per day, nicotine dependence, cannabis initiation, and cannabis use disorder) from eight studies were included. Significant genetic correlations were adjusted for variants associated with major depressive disorder and schizophrenia. Total study sample sizes per phenotype ranged from similar to 2400 to similar to 537 000 individuals. We used linkage disequilibrium score regression to calculate single nucleotide polymorphism-based genetic correlations between eating disorder- and substance-use-related phenotypes. Significant positive genetic associations emerged between AUD and AN (r(g) = 0.18; false discovery rate q = 0.0006), cannabis initiation and AN (r(g) = 0.23; q < 0.0001), and cannabis initiation and AN with binge eating (r(g) = 0.27; q = 0.0016). Conversely, significant negative genetic correlations were observed between three nondiagnostic smoking phenotypes (smoking initiation, current smoking, and cigarettes per day) and AN without binge eating (r(gs) = -0.19 to -0.23; qs < 0.04). The genetic correlation between AUD and AN was no longer significant after co-varying for major depressive disorder loci. The patterns of association between eating disorder- and substance-use-related phenotypes highlights the potentially complex and substance-specific relationships among these behaviors.

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Language(s): eng - English
 Dates: 2021
 Publication Status: Published online
 Pages: 20
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: ISI: 000513571200001
DOI: 10.1111/adb.12880
 Degree: -

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Title: ADDICTION BIOLOGY
Source Genre: Journal
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Publ. Info: 111 RIVER ST, HOBOKEN 07030-5774, NJ USA : WILEY
Pages: - Volume / Issue: 26 (1) Sequence Number: e12880 Start / End Page: - Identifier: ISSN: 1355-6215