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  Identify the “single unit” of neurovascular coupling by single-vessel fMRI and optogenetics

Wang, M., He, Y., Tang, Y., Merkle, H., & Yu, X. (2015). Identify the “single unit” of neurovascular coupling by single-vessel fMRI and optogenetics. Poster presented at 23rd Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2015), Toronto, Canada.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-002A-45E5-F Version Permalink: https://hdl.handle.net/21.11116/0000-0006-9B88-2
Genre: Poster

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http://www.ismrm.org/15/program_files/WedTP03.htm (Publisher version)
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 Creators:
Wang, M1, 2, Author           
He, Y1, 2, Author           
Tang, Y1, 2, Author           
Merkle, H1, Author           
Yu, X1, 2, Author           
Affiliations:
1Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              
2Research Group Translational Neuroimaging and Neural Control, Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_2528695              

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 Abstract: It has been demonstrated that the hemodynamic signal from individual venules can be detected directly with fMRI. Here, the hemodynamic signal from BOLD and CBV fMRI was measured at high temporal(100ms) and spatial resolution(150x150µm) in layer 4/5 of the rat forepaw S1with fast gradient-echo MRI. Distinctly different voxels were activated in BOLD vs CBV fMRI. In contrast to the BOLD activated voxels primarily located at the penetrating venules, CBV activated voxels were primarily located at penetrating arterioles. This result makes it possible to directly image the CBV and BOLD response at the single-vessel level to understand neurovascular coupling.

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 Dates: 2015-06
 Publication Status: Issued
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 Identifiers: BibTex Citekey: WangHTMY2015
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Title: 23rd Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2015)
Place of Event: Toronto, Canada
Start-/End Date: 2015-05-30 - 2015-06-05

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Title: 23rd Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2015)
Source Genre: Proceedings
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Pages: - Volume / Issue: - Sequence Number: 2041 Start / End Page: - Identifier: -