Deutsch
 
Hilfe Datenschutzhinweis Impressum
  DetailsucheBrowse

Datensatz

 
 
DownloadE-Mail
  Perturbation of Arabidopsis Amino Acid Metabolism Causes Incompatibility with the Adapted Biotrophic Pathogen Hyaloperonospora arabidopsidis

Stuttmann, J., Hubberten, H.-M., Rietz, S., Kaur, J., Muskett, P., Guerois, R., et al. (2011). Perturbation of Arabidopsis Amino Acid Metabolism Causes Incompatibility with the Adapted Biotrophic Pathogen Hyaloperonospora arabidopsidis. Plant Cell, 23(7), 2788-2803. doi:10.1105/tpc.111.087684.

Item is

Dateien

einblenden: Dateien
ausblenden: Dateien
:
Stuttmann-2011-Perturbation of Arab.pdf (beliebiger Volltext), 2MB
Name:
Stuttmann-2011-Perturbation of Arab.pdf
Beschreibung:
-
OA-Status:
Sichtbarkeit:
Öffentlich
MIME-Typ / Prüfsumme:
application/pdf / [MD5]
Technische Metadaten:
Copyright Datum:
-
Copyright Info:
-
Lizenz:
-

Externe Referenzen

einblenden:

Urheber

einblenden:
ausblenden:
 Urheber:
Stuttmann, J.1, Autor
Hubberten, H.-M.2, Autor           
Rietz, S.1, Autor
Kaur, J.1, Autor
Muskett, P.1, Autor
Guerois, R.1, Autor
Bednarek, P.1, Autor
Hoefgen, R.2, Autor           
Parker, J. E.1, Autor
Affiliations:
1External Organizations, ou_persistent22              
2Amino Acid and Sulfur Metabolism, Department Willmitzer, Max Planck Institute of Molecular Plant Physiology, Max Planck Society, ou_1753337              

Inhalt

einblenden:
ausblenden:
Schlagwörter: cystathionine gamma-synthase downy mildew resistance disease resistance aspartate kinase peronospora-parasitica salicylic-acid powdery mildew dihydrodipicolinate synthase lysine biosynthesis signaling pathways
 Zusammenfassung: Reliance of biotrophic pathogens on living plant tissues to propagate implies strong interdependence between host metabolism and nutrient uptake by the pathogen. However, factors determining host suitability and establishment of infection are largely unknown. We describe a loss-of-inhibition allele of ASPARTATE KINASE2 and a loss-of-function allele of DIHYDRODIPICOLINATE SYNTHASE2 identified in a screen for Arabidopsis thaliana mutants with increased resistance to the obligate biotrophic oomycete Hyaloperonospora arabidopsidis (Hpa). Through different molecular mechanisms, these mutations perturb amino acid homeostasis leading to overaccumulation of the Asp-derived amino acids Met, Thr, and Ile. Although detrimental for the plant, the mutations do not cause defense activation, and both mutants retain full susceptibility to the adapted obligate biotrophic fungus Golovinomyces orontii (Go). Chemical treatments mimicking the mutants' metabolic state identified Thr as the amino acid suppressing Hpa but not Go colonization. We conclude that perturbations in amino acid homeostasis render the mutant plants unsuitable as an infection substrate for Hpa. This may be explained by deployment of the same amino acid biosynthetic pathways by oomycetes and plants. Our data show that the plant host metabolic state can, in specific ways, influence the ability of adapted biotrophic strains to cause disease.

Details

einblenden:
ausblenden:
Sprache(n): eng - English
 Datum: 2011-07-222011
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: -
 Identifikatoren: ISI: ISI:000294164300028
DOI: 10.1105/tpc.111.087684
ISSN: 1040-4651
URI: ://000294164300028 http://www.plantcell.org/content/23/7/2788.full.pdf
 Art des Abschluß: -

Veranstaltung

einblenden:

Entscheidung

einblenden:

Projektinformation

einblenden:

Quelle 1

einblenden:
ausblenden:
Titel: Plant Cell
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: -
Seiten: - Band / Heft: 23 (7) Artikelnummer: - Start- / Endseite: 2788 - 2803 Identifikator: -