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  Differential tinnitus-related neuroplastic alterations of cortical thickness and surface area

Meyer, M., Neff, P., Liem, F., Kleinjung, T., Weidt, S., Langguth, B., et al. (2016). Differential tinnitus-related neuroplastic alterations of cortical thickness and surface area. Hearing Research, 342, 1-12. doi:10.1016/j.heares.2016.08.016.

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 Urheber:
Meyer, Martin1, 2, 3, Autor
Neff, Patrick1, 2, 4, Autor
Liem, Franz5, Autor           
Kleinjung, Tobias6, Autor
Weidt, Steffi7, Autor
Langguth, Berthold8, 9, Autor
Schecklmann, Martin8, 9, Autor
Affiliations:
1Neuroplasticity and Learning of the Healthy Aging Brain, Department of Psychology, University of Zurich, Switzerland, ou_persistent22              
2University Research Priority Program “Dynamics of Healthy Aging”, University of Zurich, Switzerland, ou_persistent22              
3Cognitive Psychology Unit (CPU), University of Klagenfurt, Austria, ou_persistent22              
4Institute for Computer Music and Sound Technology (ICST), University of Arts Zurich, Switzerland, ou_persistent22              
5Max Planck Research Group Neuroanatomy and Connectivity, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_1356546              
6Department of Otorhinolaryngology, University Hospital Zurich, Switzerland, ou_persistent22              
7Department of Psychiatry and Psychotherapy, University Hospital Zurich, Switzerland, ou_persistent22              
8Department for Psychiatry and Psychotherapy, University of Regensburg, Germany, ou_persistent22              
9Multidisciplinary Tinnitus Clinic at the University of Regensburg, Germany, ou_persistent22              

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Schlagwörter: Tinnitus; Surface-based morphometry; Neuroanatomy; Cortical thickness; Cortical surface area
 Zusammenfassung: Structural neuroimaging techniques have been used to identify cortical and subcortical regions constituting the neuroarchitecture of tinnitus. One recent investigation used voxel-based morphometry (VBM) to analyze a sample of tinnitus patients (TI, n = 257) (Schecklmann et al., 2013). A negative relationship between individual distress and cortical volume (CV) in bilateral auditory regions was observed. However, CV has meanwhile been identified as a neuroanatomical measurement that confounds genetically distinct neuroanatomical traits, namely cortical thickness (CT) and cortical surface area (CSA). We performed a re-analysis of the identical sample using the automated FreeSurfer surface-based morphometry (SBM) approach (Fischl, 2012). First, we replicated the negative correlation between tinnitus distress and bilateral supratemporal gray matter volume. Second, we observed a negative correlation for CSA in the left periauditory cortex and anterior insula. Furthermore, we noted a positive correlation between tinnitus duration and CT in the left periauditory cortex as well as a negative correlation in the subcallosal anterior cingulate, a region collated to the serotonergic circuit and germane to inhibitory functions.

In short, the results elucidate differential neuroanatomical alterations of CSA and CT for the two independent tinnitus-related psychological traits distress and duration. Beyond this, the study provides further evidence for the distinction and specific susceptibility of CSA and CT within the context of neuroplasticity of the human brain.

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Sprache(n): eng - English
 Datum: 2016-08-262015-12-212016-08-312016-09-232016-12
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: DOI: 10.1016/j.heares.2016.08.016
PMID: 27671157
Anderer: Epub 2016
 Art des Abschluß: -

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Titel: Hearing Research
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: Amsterdam : Elsevier
Seiten: - Band / Heft: 342 Artikelnummer: - Start- / Endseite: 1 - 12 Identifikator: ISSN: 0378-5955
CoNE: https://pure.mpg.de/cone/journals/resource/954925527845