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  Phosphorylation-regulated axonal dependent transport of syntaxin 1 is mediated by a Kinesin-1 adapter

Chua, J. J., Butkevich, E., Worseck, J. M., Kittelmann, M., Gronborg, M., Behrmann, E., et al. (2012). Phosphorylation-regulated axonal dependent transport of syntaxin 1 is mediated by a Kinesin-1 adapter. Proceedings of the National Academy of Sciences of the United States of America, 109(15), 5862-5867. doi:10.1073/pnas.1113819109.

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Datensatz-Permalink: https://hdl.handle.net/11858/00-001M-0000-0028-63D1-F Versions-Permalink: https://hdl.handle.net/11858/00-001M-0000-002B-6151-8
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Chua-2012-Phosphorylation-regulated axonal dep.pdf (beliebiger Volltext), 898KB
 
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http://www.ncbi.nlm.nih.gov/pubmed/22451907 (beliebiger Volltext)
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3326461/pdf/pnas.201113819.pdf (beliebiger Volltext)
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 Urheber:
Chua, J. J., Autor
Butkevich, E., Autor
Worseck, J. M., Autor
Kittelmann, M., Autor
Gronborg, M., Autor
Behrmann, E.1, Autor
Stelzl, U., Autor
Pavlos, N. J., Autor
Lalowski, M. M., Autor
Eimer, S., Autor
Wanker, E. E., Autor
Klopfenstein, D. R., Autor
Jahn, R., Autor
Affiliations:
1External Organizations, ou_persistent22              

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Schlagwörter: Adaptor Proteins, Signal Transducing/*metabolism Animals *Axonal Transport Axons/metabolism Caenorhabditis elegans/metabolism Caenorhabditis elegans Proteins/*metabolism HEK293 Cells Humans Kinesin/*metabolism Munc18 Proteins/metabolism Mutant Proteins/metabolism Mutation/genetics Nerve Tissue Proteins/*metabolism Neuropeptides/*metabolism Phosphorylation Protein Binding Protein Transport Syntaxin 1/*metabolism
 Zusammenfassung: Presynaptic nerve terminals are formed from preassembled vesicles that are delivered to the prospective synapse by kinesin-mediated axonal transport. However, precisely how the various cargoes are linked to the motor proteins remains unclear. Here, we report a transport complex linking syntaxin 1a (Stx) and Munc18, two proteins functioning in synaptic vesicle exocytosis at the presynaptic plasma membrane, to the motor protein Kinesin-1 via the kinesin adaptor FEZ1. Mutation of the FEZ1 ortholog UNC-76 in Caenorhabditis elegans causes defects in the axonal transport of Stx. We also show that binding of FEZ1 to Kinesin-1 and Munc18 is regulated by phosphorylation, with a conserved site (serine 58) being essential for binding. When expressed in C. elegans, wild-type but not phosphorylation-deficient FEZ1 (S58A) restored axonal transport of Stx. We conclude that FEZ1 operates as a kinesin adaptor for the transport of Stx, with cargo loading and unloading being regulated by protein kinases.

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 Datum: 2012
 Publikationsstatus: Erschienen
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 Identifikatoren: Anderer: 22451907
DOI: 10.1073/pnas.1113819109
ISSN: 1091-6490 (Electronic)
ISSN: 0027-8424 (Linking)
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Titel: Proceedings of the National Academy of Sciences of the United States of America
  Alternativer Titel : Proc. Natl. Acad. Sci. USA
Genre der Quelle: Zeitschrift
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Seiten: - Band / Heft: 109 (15) Artikelnummer: - Start- / Endseite: 5862 - 5867 Identifikator: -