English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
 
 
DownloadE-Mail
 Local TagsRelease HistoryDetailsSummary
  Impact of order and disorder in RGD nanopatterns on cell adhesion

Huang, J., Gräter, S., Corbellini, F., Rinck, S., Bock, E., Kemkemer, R., et al. (2009). Impact of order and disorder in RGD nanopatterns on cell adhesion. Nano Letters, 9(3), 1111-1116. doi:10.1021/nl803548b.

Item is

 

show all hide all

Basic

show hide
Item Permalink: https://hdl.handle.net/11858/00-001M-0000-0010-3DA9-6 Version Permalink: https://hdl.handle.net/11858/00-001M-0000-002E-5DD7-B
Genre: Journal Article

Files

show Files
hide Files
:
NanoLett_9_2009_1111.pdf (Any fulltext), 3MB
 
File Permalink:
-
Name:
NanoLett_9_2009_1111.pdf
Description:
-
OA-Status:
Visibility:
Restricted (Max Planck Institute for Medical Research, MHMF; )
MIME-Type / Checksum:
application/pdf
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-
:
NanoLett_9_2009_1111_Suppl.pdf (Supplementary material), 149KB
 
File Permalink:
-
Name:
NanoLett_9_2009_1111_Suppl.pdf
Description:
-
OA-Status:
Visibility:
Restricted (Max Planck Institute for Medical Research, MHMF; )
MIME-Type / Checksum:
application/pdf
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-

Locators

show
hide
Locator:
http://pubs.acs.org/doi/pdf/10.1021/nl803548b (Any fulltext)
Description:
-
OA-Status:
Locator:
https://dx.doi.org/10.1021/nl803548b (Any fulltext)
Description:
-
OA-Status:
Locator:
http://pubs.acs.org/doi/suppl/10.1021/nl803548b (Supplementary material)
Description:
-
OA-Status:

Creators

show
hide
 Creators:
Huang, Jinghuan, Author
Gräter, Stefan1, Author           
Corbellini, Francesca1, Author           
Rinck, Sabine1, Author           
Bock, Eva1, 2, Author           
Kemkemer, Ralf1, Author           
Kessler, Horst, Author
Ding, Jiandong, Author
Spatz, Joachim P.1, 2, Author           
Affiliations:
1Cellular Biophysics, Max Planck Institute for Medical Research, Max Planck Society, ou_2364731              
2Biophysical Chemistry, Institute of Physical Chemistry, University of Heidelberg, 69120 Heidelberg, Germany, ou_persistent22              

Content

show
hide
Free keywords: MPI für Intelligente Systeme; Abt. Spatz;
 Abstract: We herein present a novel platform of well-controlled ordered and disordered nanopatterns positioned with a cyclic peptide of arginine-glycine-aspartic acid (RGD) on a bioinert poly(ethylene glycol) background, to study whether the nanoscopic order of spatial patterning of the integrin-specific ligands influences osteoblast adhesion. This is the first time that the nanoscale order of RGD ligand patterns was varied quantitatively, and tested for its impact on the adhesion of tissue cells. Our findings reveal that integrin clustering and such adhesion induced by RGD ligands is dependent on the local order of ligand arrangement on a substrate when the global average ligand spacing is larger than 70 nm; i.e., cell adhesion is "turned off" by RGD nanopattern order and "turned on" by the RGD nanopattern disorder if operating at this range of interligand spacing.

Details

show
hide
Language(s): eng - English
 Dates: 2009
 Publication Status: Issued
 Pages: 6
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 429026
DOI: 10.1021/nl803548b
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Nano Letters
  Abbreviation : Nano Lett.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Washington, DC : American Chemical Society
Pages: - Volume / Issue: 9 (3) Sequence Number: - Start / End Page: 1111 - 1116 Identifier: ISSN: 1530-6984
CoNE: https://pure.mpg.de/cone/journals/resource/110978984570403