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  Transcranial direct current stimulation over the sensory‐motor regions inhibits gamma synchrony

Pellegrino, G., Arcara, G., Di Pino, G., Turco, C., Maran, M., Weis, L., et al. (2019). Transcranial direct current stimulation over the sensory‐motor regions inhibits gamma synchrony. Human Brain Mapping, 40(9), 2736-2746. doi:10.1002/hbm.24556.

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Item Permalink: https://hdl.handle.net/21.11116/0000-0004-D3AF-9 Version Permalink: https://hdl.handle.net/21.11116/0000-0007-000E-A
Genre: Journal Article

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 Creators:
Pellegrino, Giovanni1, Author
Arcara, Giorgio1, Author
Di Pino, Giovanni2, Author
Turco, Cristina1, Author
Maran, Matteo1, Author           
Weis, Luca1, Author
Piccione, Francesco1, Author
Siebner, Hartwig Roman3, 4, Author
Affiliations:
1Brain Imaging and Neural Dynamics Research Group, Scientific Institute for Research, Hospitalization and Health Care (IRCCS), Hospital San Camillo, Venice, Italy, ou_persistent22              
2Department of Neurology, NeXT: Neurophysiology and Neuroengineering of Human-Technology Interaction Research Unit,Campus Bio-Medico University, Rome, Italy, ou_persistent22              
3Danish Research Centre for Magnetic Resonance, Copenhagen University Hospital Hvidovre, Denmark, ou_persistent22              
4Department of Neurology, Bispebjerg Hospital, Copenhagen, Denmark, ou_persistent22              

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Free keywords: ASSR; Auditory stated state responses; Gamma; Magnetoencephalography; MEG; Synchrony; tDCS
 Abstract: Transcranial direct current stimulation (tDCS) is a noninvasive brain stimulation technique able to induce plasticity phenomena. Although tDCS application has been spreading over a variety of neuroscience domains, the mechanisms by which the stimulation acts are largely unknown. We investigated tDCS effects on cortical gamma synchrony, which is a crucial player in cortical function. We performed a randomized, sham‐controlled, double‐blind study on healthy subjects, combining tDCS and magnetoencephalography. By driving brain activity via 40 Hz auditory stimulation during magnetoencephalography, we experimentally tuned cortical gamma synchrony and measured it before and after bilateral tDCS of the primary sensory‐motor hand regions (anode left, cathode right). We demonstrated that the stimulation induces a remarkable decrease of gamma synchrony (13 out of 15 subjects), as measured by gamma phase at 40 Hz. tDCS has strong remote effects, as the cortical region mostly affected was located far away from the stimulation site and covered a large area of the right centro‐temporal cortex. No significant differences between stimulations were found for baseline gamma synchrony, as well as early transient auditory responses. This suggests a specific tDCS effect on externally driven gamma synchronization. This study sheds new light on the effect of tDCS on cortical function showing that the net effect of the stimulation on cortical gamma synchronization is an inhibition.

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Language(s): eng - English
 Dates: 2019-01-272018-11-112019-02-202019-05-092019-06-15
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1002/hbm.24556
PMID: 30854728
Other: Epub 2019
 Degree: -

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Project name : -
Grant ID : R59‐A5399
Funding program : Grant of Excellence “Mapping, Modulation and Modelling the Control of Actions”
Funding organization : Lundbeckfonden
Project name : Interdisciplinary Synergy Program 2014
Grant ID : NNF14OC0011413
Funding program : Synergy Grant
Funding organization : Novo Nordisk Foundation
Project name : REstoring the Self with embodiable HAnd ProsthesEs / RESHAPE
Grant ID : 678908
Funding program : Horizon 2020
Funding organization : European Commission (EC)

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Title: Human Brain Mapping
Source Genre: Journal
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Publ. Info: -
Pages: - Volume / Issue: 40 (9) Sequence Number: - Start / End Page: 2736 - 2746 Identifier: ISSN: 1065-9471
CoNE: https://pure.mpg.de/cone/journals/resource/954925601686