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  Neuroticism, depression, and anxiety traits exacerbate the state of cognitive impairment and hippocampal vulnerability to Alzheimer's disease

Zufferey, V., Donati, A., Popp, J., Meuli, R., Rossier, J., Frackowiak, R., et al. (2017). Neuroticism, depression, and anxiety traits exacerbate the state of cognitive impairment and hippocampal vulnerability to Alzheimer's disease. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, 7, 107-114. doi:10.1016/j.dadm.2017.05.002.

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Item Permalink: https://hdl.handle.net/21.11116/0000-0004-AB29-E Version Permalink: https://hdl.handle.net/21.11116/0000-0004-DCBE-F
Genre: Journal Article

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 Creators:
Zufferey, Valérie1, 2, Author
Donati, Alessia2, Author
Popp, Julius2, Author
Meuli, Reto3, Author
Rossier, Jerome4, Author
Frackowiak, Richard1, Author
Draganski, Bogdan1, 5, Author           
von Gunten, Armin2, Author
Kherif, Ferath1, Author
Affiliations:
1Laboratoire de Recherche en Neuroimagerie (LREN), Centre hospitalier universitaire vaudois, Lausanne, Switzerland, ou_persistent22              
2Department of Psychiatry, Centre hospitalier universitaire vaudois, Lausanne, Switzerland, ou_persistent22              
3Department of Radiology, Centre hospitalier universitaire vaudois, Lausanne, Switzerland, ou_persistent22              
4Faculty of Social and Political Sciences, University of Lausanne, Switzerland, ou_persistent22              
5Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              

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Free keywords: Alzheimer's disease; Brain; Personality; Neuroimaging; Psychiatry; Prognosis
 Abstract: INTRODUCTION:

Certain personality traits are associated with higher risk of Alzheimer's disease, similar to cognitive impairment. The identification of biological markers associated with personality in mild cognitive impairment could advance the early detection of Alzheimer's disease.
METHODS:

We used hierarchical multivariate linear models to quantify the interaction between personality traits, state of cognitive impairment, and MRI biomarkers (gray matter brain volume, gray matter mean water diffusion) in the medial temporal lobe (MTL).
RESULTS:

Over and above a main effect of cognitive state, the multivariate linear model showed significant interaction between cognitive state and personality traits predicting MTL abnormality. The interaction effect was mainly driven by neuroticism and its facets (anxiety, depression, and stress) and was associated with right-left asymmetry and an anterior to posterior gradient in the MTL.
DISCUSSION:

Our results support the hypothesis that personality traits can alter the vulnerability and pathoplasticity of disease and therefore modulate related biomarker expression.

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Language(s): eng - English
 Dates: 2017-05-31
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1016/j.dadm.2017.05.002
PMC: PMC5476972
PMID: 28653033
Other: eCollection 2017
 Degree: -

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Project name : -
Grant ID : 3200BO-122263
Funding program : -
Funding organization : Swiss National Science Foundation
Project name : NCCR Synapsy
Grant ID : 320030_135679 ; 33CM30_140332/1
Funding program : -
Funding organization : Swiss National Science Foundation
Project name : -
Grant ID : -
Funding program : -
Funding organization : Foundation Parkinson Switzerland
Project name : -
Grant ID : -
Funding program : -
Funding organization : Foundation Synapsis
Project name : -
Grant ID : -
Funding program : -
Funding organization : Novartis Foundation for Medical Biological Research
Project name : Tiefe Hirnstimulation: Wirkmechanismus, Kortex-Basalganglien - Physiologie und Therapieoptimierung / KFO 247
Grant ID : -
Funding program : -
Funding organization : German Research Foundation (DFG)
Project name : -
Grant ID : -
Funding program : -
Funding organization : Roger de Spoelberg and Partridge Foundations
Project name : The Human Brain Project / HBP
Grant ID : 604102
Funding program : Funding Programme 7
Funding organization : European Commission (EC)
Project name : Human Brain Project Specific Grant Agreement 1 / HBP SGA1
Grant ID : 720270
Funding program : Horizon 2020
Funding organization : European Commission (EC)
Project name : -
Grant ID : -
Funding program : -
Funding organization : VELUX Stiftung
Project name : -
Grant ID : -
Funding program : -
Funding organization : Pharnext, Paris

Source 1

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Title: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Amsterdam : Elsevier
Pages: - Volume / Issue: 7 Sequence Number: - Start / End Page: 107 - 114 Identifier: ISSN: 2352-8729
CoNE: https://pure.mpg.de/cone/journals/resource/2352-8729