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  Tumour-targeted drug delivery with mannose-functionalized nanoparticles self-assembled from amphiphilic β-cyclodextrins

Ye, Z., Zhang, Q., Wang, S., Bharate, P., Varela-Aramburu, S., Lu, M., et al. (2016). Tumour-targeted drug delivery with mannose-functionalized nanoparticles self-assembled from amphiphilic β-cyclodextrins. Chemistry – A European Journal, 22(43), 15216-15221. doi:10.1002/chem.201603294.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-002B-78B1-6 Version Permalink: https://hdl.handle.net/21.11116/0000-0006-6131-5
Genre: Journal Article

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 Creators:
Ye, Zhou1, Author           
Zhang, Quan1, Author
Wang, Shengtao, Author
Bharate, Priya1, Author           
Varela-Aramburu, Silvia1, Author           
Lu, Mengji, Author
Seeberger, Peter H.2, Author           
Yin, Jian, Author
Affiliations:
1Peter H. Seeberger - Nanoparticles and Colloidal Polymers, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_1863307              
2Peter H. Seeberger - Automated Systems, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_1863306              

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Free keywords: cancer chemotherapy, mannose-mediated targeting, multivalency, nanoparticles, targeted drug delivery
 Abstract: Multivalent mannose-functionalized nanoparticles self-assembled from amphiphilic β-cyclodextrins (β-CDs) facilitate the targeted delivery of anticancer drugs to specific cancer cells. Doxorubicin (DOX)-loaded nanoparticles equipped with multivalent mannose target units were efficiently taken up via receptor-mediated endocytosis by MDA-MB-231 breast cancer cells that overexpress the mannose receptor. Upon entering the cell, the intracellular pH causes the release of DOX, which triggers apoptosis. Targeting by multivalent mannose significantly improved the capability of DOX-loaded nanoparticles to inhibit the growth of MDA-MB-231 cancer cells with minimal side effects in vivo. This targeted and controlled drug delivery system holds promise as a nanotherapeutic for cancer treatment.

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 Dates: 2016-09-222016
 Publication Status: Issued
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 Identifiers: DOI: 10.1002/chem.201603294
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Title: Chemistry – A European Journal
  Other : Chem. – Eur. J.
  Other : Chem. Eur. J.
Source Genre: Journal
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Publ. Info: Weinheim, Germany : Wiley-VCH
Pages: - Volume / Issue: 22 (43) Sequence Number: - Start / End Page: 15216 - 15221 Identifier: ISSN: 0947-6539