Deutsch
 
Hilfe Datenschutzhinweis Impressum
  DetailsucheBrowse

Datensatz

 
 
DownloadE-Mail
  Viscoelastic properties of vimentin originate from nonequilibrium conformational changes

Block, J., Witt, H., Candelli, A., Danes, J. C., Peterman, E. J. G., Wuite, G. J. L., et al. (2018). Viscoelastic properties of vimentin originate from nonequilibrium conformational changes. Science Advances, 4(6): eaat1161. doi:10.1126/sciadv.aat1161.

Item is

Basisdaten

einblenden: ausblenden:
Genre: Zeitschriftenartikel

Externe Referenzen

einblenden:

Urheber

einblenden:
ausblenden:
 Urheber:
Block, J., Autor
Witt, Hannes1, Autor           
Candelli, A., Autor
Danes, J. C., Autor
Peterman, E. J. G., Autor
Wuite, G. J. L., Autor
Janshoff, A., Autor
Köster, S., Autor
Affiliations:
1Max Planck Fellow Group Membrane-based biomimetic nano- and micro-compartments, Max Planck Institute for Dynamics and Self-Organization, Max Planck Society, ou_2586691              

Inhalt

einblenden:
ausblenden:
Schlagwörter: -
 Zusammenfassung: Structure and dynamics of living matter rely on design principles fundamentally different from concepts of traditional material science. Specialized intracellular filaments in the cytoskeleton permit living systems to divide, migrate, and grow with a high degree of variability and durability. Among the three filament systems, microfilaments, microtubules, and intermediate filaments (IFs), the physical properties of IFs and their role in cellular mechanics are the least well understood. We use optical trapping of individual vimentin filaments to investigate energy dissipation, strain history dependence, and creep behavior of stretched filaments. By stochastic and numerical modeling, we link our experimental observations to the peculiar molecular architecture of IFs. We find that individual vimentin filaments display tensile memory and are able to dissipate more than 70% of the input energy. We attribute these phenomena to distinct non equilibrium folding and unfolding of a helices in the vimentin monomers constituting the filaments.

Details

einblenden:
ausblenden:
Sprache(n): eng - English
 Datum: 2018-06-132018-06-01
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: DOI: 10.1126/sciadv.aat1161
 Art des Abschluß: -

Veranstaltung

einblenden:

Entscheidung

einblenden:

Projektinformation

einblenden:

Quelle 1

einblenden:
ausblenden:
Titel: Science Advances
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: -
Seiten: 11 Band / Heft: 4 (6) Artikelnummer: eaat1161 Start- / Endseite: - Identifikator: -