English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
 
 
DownloadE-Mail
 Local TagsRelease HistoryDetailsSummary
  Combination therapy with amphotericin B and doxorubicin encapsulated in mannosylated nanomicelles for visceral leishmaniasis

Wei, P., Ye, Z., Cao, S., Bai, S., Seeberger, P. H., Yin, J., et al. (2020). Combination therapy with amphotericin B and doxorubicin encapsulated in mannosylated nanomicelles for visceral leishmaniasis. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 598: 124804. doi:10.1016/j.colsurfa.2020.124804.

Item is

 

show all hide all

Basic

show hide
Item Permalink: https://hdl.handle.net/21.11116/0000-0006-4D0A-A Version Permalink: https://hdl.handle.net/21.11116/0000-0006-9EEC-F
Genre: Journal Article

Files

show Files
hide Files
:
Article.pdf (Publisher version), 2MB
 
File Permalink:
-
Name:
Article.pdf
Description:
-
OA-Status:
Visibility:
Restricted (Max Planck Institute of Colloids and Interfaces, MTKG; )
MIME-Type / Checksum:
application/pdf
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-

Locators

show

Creators

show
hide
 Creators:
Wei, Peng, Author
Ye, Zhou, Author
Cao, Shuya, Author
Bai, Shuo, Author
Seeberger, Peter H.1, Author           
Yin, Jian, Author
Hu, Jing, Author
Affiliations:
1Peter H. Seeberger, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_2040285              

Content

show
hide
Free keywords: Nanomicelle, Leishmaniasis, Mannose receptor
 Abstract: Drugs used to treat visceral leishmaniasis (VL) have severe side effects and face increasing resistance. We have created a mannose-functionalized nanomicelle carrying two drugs amphotericin B (AmB) and doxorubicin (DOX). The nanomicelles AmB&DOX@MCC preferentially target macrophages where Leishmania parasites reside and replicate, by the interaction between mannose residues on the micelle and mannose receptors (MRs) on the macrophage membrane. The combination of AmB and DOX leads to enhanced anti-leishmanial therapeutic efficacy through a synergistic effect. The mannose-fabricated nanomicelle is a promising formulation for leishmaniasis treatment.

Details

show
hide
Language(s): eng - English
 Dates: 2020-04-122020
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1016/j.colsurfa.2020.124804
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Colloids and Surfaces A: Physicochemical and Engineering Aspects
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Amsterdam : Elsevier
Pages: - Volume / Issue: 598 Sequence Number: 124804 Start / End Page: - Identifier: ISSN: 0927-7757