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  Chip printer

Cheng, Y. C., Löffler, F., Koenig, K., Nesterov, A., Doersam, E., & Breitling, F. (2010). Chip printer. In Advanced Research in Physics and Engineering: Proceedings of the 2nd WSEAS International Conference on NANOTECHNOLOGY (pp. 19-22).

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-002C-50FD-F Version Permalink: https://hdl.handle.net/11858/00-001M-0000-002C-50FE-D
Genre: Conference Paper

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 Creators:
Cheng, Yun Chien, Author
Löffler, Felix1, Author           
Koenig, Kai, Author
Nesterov, Alexander, Author
Doersam, Edgar, Author
Breitling, Frank, Author
Affiliations:
1External Organizations, ou_persistent22              

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 Abstract: Lithographic methods allow for the combinatorial synthesis of >50.000 oligonucleotides per cm(2), which revolutionized the field of genomics. High density peptide arrays promise to advance the field of proteomics in a similar way, but until recently were not available. This is mainly due to the monomer-by-monomer repeated consecutive coupling of 20 different amino acids associated with lithography, which adds up to an excessive number of coupling cycles. A combinatorial synthesis based on electrically charged solid amino acid particles resolves this problem. Here we report the manufacturing of a "chip printer" that could be used to consecutively address the different charged particles to a solid support, where, when completed, the whole layer of solid amino acid particles is melted at once. This frees hitherto immobilized amino acids to couple all 20 different amino acids in one single coupling reaction to the support. The method should allow for the synthesis of very high-density peptide arrays.

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 Dates: 2010
 Publication Status: Issued
 Pages: -
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 Rev. Type: -
 Identifiers: ISI: 000276890000001
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Title: 2nd WSEAS International Conference on Nanotechnology/5th WSEAS International Conference on Optics Astrophysics-Astronomy /1st WSEAS International Conference Plasma, Fusion, Nuclear Physics
Place of Event: Univ Cambridge, Cambridge, ENGLAND
Start-/End Date: 2010-02-20 - 2010-02-22

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Title: Advanced Research in Physics and Engineering: Proceedings of the 2nd WSEAS International Conference on NANOTECHNOLOGY
Source Genre: Proceedings
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Pages: - Volume / Issue: - Sequence Number: - Start / End Page: 19 - 22 Identifier: ISBN: 978-960-474-163-2