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  Identification of a Pre-BCR Lacking Surrogate Light Chain

Su, Y.-W., Flemming, A., Wossning, T., Hobeika, E., Reth, M., & Jumaa, H. (2003). Identification of a Pre-BCR Lacking Surrogate Light Chain. Journal of Experimental Medicine, 198(11), 1699-1706.

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 Creators:
Su, Yu-Wen1, Author           
Flemming, Alexandra1, Author           
Wossning, Thomas1, Author           
Hobeika, Elias1, Author           
Reth, Michael1, Author           
Jumaa, Hassan1, Author           
Affiliations:
1Research Group and Chair of Molecular Immunology of the University of Freiburg, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, ou_2243645              

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 Abstract: SLP-65-/- pre-B cells show a high proliferation rate in vitro. We have shown previously that λ5 expression and consequently a conventional pre-B cell receptor (pre-BCR) are essential for this proliferation. Here, we show that pre-B cells express a novel receptor complex that contains a μ heavy chain (μHC) but lacks any surrogate (SL) or conventional light chain (LC). This SL-deficient pre-BCR (SL-pre-BCR) requires Ig-α for expression on the cell surface. Anti-μ treatment of pre-B cells expressing the SL-pre-BCR induces tyrosine phosphorylation of substrate proteins and a strong calcium (Ca2+) release. Further, the expression of the SL2+-pre-BCR is associated with a high differentiation rate toward κLC-positive cells. Given that B cell development is only partially blocked and allelic exclusion is unaffected in SL-deficient mice, we propose that the SL-pre-BCR is involved in these processes and therefore shares important functions with the conventional pre-BCR.

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Language(s): eng - English
 Dates: 2003-12-01
 Publication Status: Issued
 Pages: -
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 Table of Contents: -
 Rev. Type: -
 Identifiers: eDoc: 127072
ISI: 000186990300010
 Degree: -

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Title: Journal of Experimental Medicine
  Alternative Title : J. Exp. Med.
Source Genre: Journal
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Pages: - Volume / Issue: 198 (11) Sequence Number: - Start / End Page: 1699 - 1706 Identifier: ISSN: 0022-1007