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  Insights into DDT resistance from the drosophila melanogaster genetic reference panel

Schmidt, J. M., Battlay, P., Gledhill-Smith, R. S., Good, R. T., Lumb, C., Fournier-Level, A., et al. (2017). Insights into DDT resistance from the drosophila melanogaster genetic reference panel. Genetics, 207(3), 1181-1193. doi:10.1534/genetics.117.300310.

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Schmidt_Insights_Genetics_2017.pdf (Publisher version), 848KB
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Schmidt_Insights_Genetics_2017.pdf
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2017
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Copyright © 2017 by the Genetics Society of America Available freely online through the author-supported open access option.
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 Creators:
Schmidt, Joshua M.1, Author           
Battlay, Paul, Author
Gledhill-Smith, Rebecca S., Author
Good, Robert T., Author
Lumb, Chris, Author
Fournier-Level, Alexandre, Author
Robin, Charles, Author
Affiliations:
1Selenium and Genome Annotation, Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Max Planck Society, ou_2074330              

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Free keywords: Drosophila Genetic Reference Panel (DGRP) DDT CG10737 Cyp6w1 triallele
 Abstract: Insecticide resistance is considered a classic model of microevolution, where a strong selective agent is applied to a large natural population, resulting in a change in frequency of alleles that confer resistance. While many insecticide resistance variants have been characterized at the gene level, they are typically single genes of large effect identified in highly resistant pest species. In contrast, multiple variants have been implicated in DDT resistance in Drosophila melanogaster; however, only the Cyp6g1 locus has previously been shown to be relevant to field populations. Here we use genome-wide association studies (GWAS) to identify DDT-associated polygenes and use selective sweep analyses to assess their adaptive significance. We identify and verify two candidate DDT resistance loci. A largely uncharacterized gene, CG10737, has a function in muscles that ameliorates the effects of DDT, while a putative detoxifying P450, Cyp6w1, shows compelling evidence of positive selection.

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Language(s): eng - English
 Dates: 2017-02-092017-09-182017-11-022017-11-01
 Publication Status: Issued
 Pages: 13
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1534/genetics.117.300310
 Degree: -

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Title: Genetics
Source Genre: Journal
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Publ. Info: Genetics Society of America
Pages: - Volume / Issue: 207 (3) Sequence Number: - Start / End Page: 1181 - 1193 Identifier: ISSN: 0016-6731
CoNE: https://pure.mpg.de/cone/journals/resource/954925400554