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Free keywords:
dynamical systems; gene drive; genetic pest management; population transformation; population replacement
Abstract:
Background: Transgenic constructs intended to be stably established at high frequencies in wild populations have
been demonstrated to “drive” from low frequencies in experimental insect populations. Linking such population
transformation constructs to genes which render them unable to transmit pathogens could eventually be used to
stop the spread of vector-borne diseases like malaria and dengue.
Results: Generally, population transformation constructs with only a single transgenic drive mechanism have been
envisioned. Using a theoretical modelling approach we describe the predicted properties of a construct combining
autosomal Medea and underdominant population transformation systems. We show that when combined they can
exhibit synergistic properties which in broad circumstances surpass those of the single systems.
Conclusion: With combined systems, intentional population transformation and its reversal can be achieved readily.
Combined constructs also enhance the capacity to geographically restrict transgenic constructs to targeted
populations. It is anticipated that these properties are likely to be of particular value in attracting regulatory approval
and public acceptance of this novel technology.
