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  GABA promotes beta-Amyloid related changes in dynamic network expression of elderly subjects at risk for Alzheimer's disease

Quevenco, F.-C., Schreiner, S., Preti, M., van Bergen, J., Kirchner, T., Wyss, M., et al. (2017). GABA promotes beta-Amyloid related changes in dynamic network expression of elderly subjects at risk for Alzheimer's disease. In 25th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2017) (pp. 668-668).

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Item Permalink: https://hdl.handle.net/21.11116/0000-0000-C59C-2 Version Permalink: https://hdl.handle.net/21.11116/0000-0000-F2D2-1
Genre: Meeting Abstract

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 Creators:
Quevenco, F-C, Author
Schreiner, S, Author
Preti, MG, Author
van Bergen, J, Author
Kirchner, T, Author
Wyss, M, Author
Steininger, S, Author
Gietl, A, Author
Leh, S, Author
Buck, A, Author
Pruessman, K, Author
Hock, C, Author
Nitsch, R, Author
Henning, A1, 2, 3, Author           
Van de Ville, D, Author
Unschuld, P, Author
Affiliations:
1Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              
2Research Group MR Spectroscopy and Ultra-High Field Methodology, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_2528692              
3Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497796              

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 Abstract: This study observes dynamic functional connectivity changes in an elderly AD-risk population mediated by both regional Aß-deposits and GABA levels, using PiB-PET and MRSI. The sample is grouped into subjects with high regional Aß and high GABA, and changes in dynamic network expression are compared between groups. Our preliminary findings show dynamic network changes specific to high Aß-deposits in the neocortex and the frontal and temporal lobe. This indicates region-specific network changes that may in part explain the weak correlation between global Aß and AD progression.

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 Dates: 2017-04-27
 Publication Status: Issued
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 Identifiers: BibTex Citekey: QuevencoSPvKWSGLBPHNHVU2017
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Title: 25th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2017)
Place of Event: Honolulu, HI, USA
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Title: 25th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2017)
Source Genre: Proceedings
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Pages: - Volume / Issue: - Sequence Number: 1154 Start / End Page: 668 - 668 Identifier: -