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  Intranasally Applied Neuropeptide S Shifts a High-Anxiety Electrophysiological Endophenotype in the Ventral Hippocampus towards a "Normal"-Anxiety One

Dine, J., Ionescu, I., Avrabos, C., Yen, Y.-C., Holsboer, F., Landgraf, R., et al. (2015). Intranasally Applied Neuropeptide S Shifts a High-Anxiety Electrophysiological Endophenotype in the Ventral Hippocampus towards a "Normal"-Anxiety One. PLOS ONE, 10(4): e0120272. doi:10.1371/journal.pone.0120272.

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Dine, Julien1, Autor           
Ionescu, Irina1, Autor           
Avrabos, Charilaos1, Autor           
Yen, Yi-Chun1, Autor           
Holsboer, Florian1, Autor           
Landgraf, Rainer1, Autor           
Schmidt, Ulrike1, Autor           
Eder, Matthias1, Autor           
Affiliations:
1Max Planck Institute of Psychiatry, Max Planck Society, ou_1607137              

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 Zusammenfassung: The neurobiological basis of pathological anxiety and the improvement of its pharmacological treatment are a matter of intensive investigation. Here, using electrophysiological techniques in brain slices from animals of the high anxiety-related behavior (HAB) and normal anxiety-related behavior (NAB) mouse model, we show that basal neurotransmission at ventral hippocampal CA3-CA1 synapses is weaker in HAB compared to NAB mice. We further demonstrate that paired-pulse facilitation (PPF) and long-term potentiation (LTP) at these synapses are more pronounced in slices from HAB animals. Based on previous findings, we also examined whether intranasal delivery of neuropeptide S (NPS), which increasingly emerges as a potential novel treatment option for anxiety symptoms occurring in a variety of diseases like anxiety disorders, posttraumatic stress disorder, and major depression, impacts on the high-anxiety electrophysiological endophenotype in HAB mice. Strikingly, we detected enhanced basal neurotransmission and reduced PPF and LTP in slices from NPS-treated HAB animals. Collectively, our study uncovers a multifaceted high-anxiety neurophysiological endophenotype in the murine ventral hippocampus and provides the first evidence that an intranasally applied neuropeptide can shift such an endophenotype in an anxiety-regulating brain structure towards a "normal"-anxiety one.

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Sprache(n): eng - English
 Datum: 2015-04-01
 Publikationsstatus: Online veröffentlicht
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 Identifikatoren: ISI: 000352135600028
DOI: 10.1371/journal.pone.0120272
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Titel: PLOS ONE
Genre der Quelle: Zeitschrift
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Ort, Verlag, Ausgabe: San Francisco, CA 94111 US : PLOS
Seiten: - Band / Heft: 10 (4) Artikelnummer: e0120272 Start- / Endseite: - Identifikator: ISSN: 1932-6203