Deutsch
 
Hilfe Datenschutzhinweis Impressum
  DetailsucheBrowse

Datensatz

 
 
DownloadE-Mail
  Quantitative magnetic resonance imaging of cortical multiple sclerosis pathology

Tardif, C., Bedell, B. J., Eskildsen, S. F., Collins, D. L., & Pike, G. B. (2012). Quantitative magnetic resonance imaging of cortical multiple sclerosis pathology. Multiple Sclerosis International, 2012: 742018. doi:10.1155/2012/742018.

Item is

Basisdaten

einblenden: ausblenden:
Genre: Zeitschriftenartikel

Dateien

einblenden: Dateien
ausblenden: Dateien
:
Tardif_2012.pdf (Verlagsversion), 8MB
Name:
Tardif_2012.pdf
Beschreibung:
-
OA-Status:
Sichtbarkeit:
Öffentlich
MIME-Typ / Prüfsumme:
application/pdf / [MD5]
Technische Metadaten:
Copyright Datum:
-
Copyright Info:
-
Lizenz:
-

Externe Referenzen

einblenden:

Urheber

einblenden:
ausblenden:
 Urheber:
Tardif, Christine1, Autor           
Bedell, Barry J.2, Autor
Eskildsen, Simon F.3, Autor
Collins, D. Louis1, Autor
Pike, G. Bruce1, Autor
Affiliations:
1McConnell Brain Imaging Centre, Montreal Neurological Institute, Montreal, Quebec, Canada, ou_persistent22              
2Small Animal Imaging Laboratory, Montreal Neurological Institute, Montreal, Quebec, Canada, ou_persistent22              
3Center for Functionally Integrative Neuroscience, Aarhus University, Aarhus, Denmark, ou_persistent22              

Inhalt

einblenden:
ausblenden:
Schlagwörter: -
 Zusammenfassung: Although significant improvements have been made regarding the visualization and characterization of cortical multiple sclerosis (MS) lesions using magnetic resonance imaging (MRI), cortical lesions (CL) continue to be under-detected in vivo, and we have a limited understanding of the causes of GM pathology. The objective of this study was to characterize the MRI signature of CLs to help interpret the changes seen in vivo and elucidate the factors limiting their visualization. A quantitative 3D high-resolution (350 μm isotropic) MRI study at 3 Tesla of a fixed post mortem cerebral hemisphere from a patient with MS is presented in combination with matched immunohistochemistry. Type III subpial lesions are characterized by an increase in T1, T2 and M0, and a decrease in MTR in comparison to the normal appearing cortex (NAC). All quantitative MR parameters were associated with cortical GM myelin content, while T1 showed the strongest correlation. The histogram analysis showed extensive overlap between CL and NAC for all MR parameters and myelin content. This is due to the poor contrast in myelin content between CL and NAC in comparison to the variability in myelo-architecture throughout the healthy cortex. This latter comparison is highlighted by the representation of T1 times on cortical surfaces at several laminar depths.

Details

einblenden:
ausblenden:
Sprache(n): eng - English
 Datum: 2012-08-142012-05-042012-09-052012-11-18
 Publikationsstatus: Online veröffentlicht
 Seiten: 13
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: DOI: 10.1155/2012/742018
PMID: 23213531
PMC: PMC3506905
Anderer: Epub 2012
 Art des Abschluß: -

Veranstaltung

einblenden:

Entscheidung

einblenden:

Projektinformation

einblenden:

Quelle 1

einblenden:
ausblenden:
Titel: Multiple Sclerosis International
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: Hindawi Publishing Corporation
Seiten: - Band / Heft: 2012 Artikelnummer: 742018 Start- / Endseite: - Identifikator: ISSN: 2090-2654
CoNE: https://pure.mpg.de/cone/journals/resource/2090-2654