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  Discovery of Mycobacterium Tuberculosis Protein Tyrosine Phosphatase A (MptpA) Inhibitors Based on Natural Products and a Fragment-Based Approach

Manger, M., Scheck, M., Prinz, H., von Kries, J. P., Langer, T., Saxena, K., et al. (2005). Discovery of Mycobacterium Tuberculosis Protein Tyrosine Phosphatase A (MptpA) Inhibitors Based on Natural Products and a Fragment-Based Approach. ChemBioChem, 6(10), 1749-1753. doi:10.1002/cbic.200500171.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-0025-AEA7-4 Version Permalink: https://hdl.handle.net/11858/00-001M-0000-0025-AEA8-2
Genre: Journal Article

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[204]SI.pdf (Supplementary material), 110KB
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https://hdl.handle.net/11858/00-001M-0000-0025-AEAE-5
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2005
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Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim
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 Creators:
Manger, Michael1, 2, Author
Scheck, Michael1, 2, Author
Prinz, Heino1, 2, Author
von Kries, Jens Peter3, 4, Author
Langer, Thomas5, Author
Saxena, Krishna5, Author
Schwalbe, Harald5, Author
Fürstner, Alois6, Author           
Rademann, Jörg3, 4, Author
Waldmann, Herbert1, 2, Author
Affiliations:
1Max-Planck-Institut für Molekulare Physiologie, Abteilung Chemische Biologie, Otto-Hahn-Straße 11, 44227 Dortmund, Germany, ou_persistent22              
2Universität Dortmund, Fachbereich 3, Organische Chemie, 44221 Dortmund, Germany, ou_persistent22              
3Leibniz Institut für Molekulare Pharmakologie (FMP), Robert-Rössle-Straße 10, 13125 Berlin, Germany, ou_persistent22              
4Freie Universität Berlin, Institut für Chemie, Takustraße 3, 14195 Berlin, Germany, ou_persistent22              
5Institut für Organische Chemie, Johann Wolfgang Goethe-Universität, Marie-Curie-Strasse 11, 60439 Frankfurt am Main, Germany, ou_persistent22              
6Research Department Fürstner, Max-Planck-Institut für Kohlenforschung, Max Planck Society, ou_1445584              

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Free keywords: enzymes; inhibitors; natural products; phosphatases; stevastelins
 Abstract: Naturally inspired or fragment based. Mcyobacterium tuberculosis has two functional phosphatases, protein tyrosine phosphates A and B (MptpA and B), which are thought to mediate mycobacterial survival in the host. Here we describe the first inhibitors of MptpA (see scheme). Initial hits were identified in screening collections that were inspired by natural products and composed by fragment-based approach.

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Language(s): eng - English
 Dates: 2005-04-212005-09-292005-10-07
 Publication Status: Issued
 Pages: 5
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1002/cbic.200500171
 Degree: -

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Title: ChemBioChem
  Other : ChemBioChem
Source Genre: Journal
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Publ. Info: Weinheim, Germany : Wiley-VCH
Pages: - Volume / Issue: 6 (10) Sequence Number: - Start / End Page: 1749 - 1753 Identifier: ISSN: 1439-4227
CoNE: https://pure.mpg.de/cone/journals/resource/110978984568897_1