English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
 
 
DownloadE-Mail
 DetailsSummary
  Oligosaccharides and oligosaccharide-protein conjugates derived from clostridium difficile polysaccharide PS-II, methods of synthesis and uses thereof, in particular as a vaccine

Seeberger, P. H., Oberli, M., & Hecht, M.-L.(2012). Oligosaccharides and oligosaccharide-protein conjugates derived from clostridium difficile polysaccharide PS-II, methods of synthesis and uses thereof, in particular as a vaccine.

Item is

 

show all hide all

Basic

show hide
Item Permalink: https://hdl.handle.net/11858/00-001M-0000-0027-5F76-B Version Permalink: https://hdl.handle.net/11858/00-001M-0000-0027-5F77-9
Genre: Patent

Files

show Files
hide Files
:
2156984.pdf (Publisher version), 2MB
View   Save
File Permalink:
https://hdl.handle.net/11858/00-001M-0000-0027-5F78-7
Name:
2156984.pdf
Description:
-
OA-Status:
Visibility:
Public
MIME-Type / Checksum:
application/pdf / [MD5]
Technical Metadata:
View
Copyright Date:
-
Copyright Info:
-
License:
-

Locators

show

Creators

show
hide
 Creators:
Seeberger, Peter H.1, Author           
Oberli, Matthias2, Author           
Hecht, Mary-Lyn2, Author           
Affiliations:
1Peter H. Seeberger, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_2040285              
2Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_1863286              

Content

show
hide
Free keywords: -
 Abstract: The present invention provides an oligosaccharide-protein conjugate comprising an oligosaccharide, in particular synthetic oligosaccharide, derived from the repeating unit of the Clostridium difjicile glycopolymer PS-II and a protein carrier. More specifically, the oligosaccharide is the hexasaccharide having the following formula (I) wherein R is a linker or spacer group. In a specific embodiment of the invention, R is (CH2)nNHz, with n being an integer from 2 to 50. The present invention also provides the use of said oligosaccharide and said oligosaccharide-protein conjugate for the treatment or prevention of a disease caused by the pathogen Clostridium difjicile. In still further aspects, the present invention also provides a favourable method for preparing said oligosaccharide and said oligosaccharide-protein conjugate.

Details

show
hide
Language(s):
 Dates: 2011-03-082012-09-13
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: Patent Application Nr.: US201161450388P
Patent Publication Nr.: WO2012119769
Patent Nr.: EP2683401
 Degree: -

Event

show

Legal Case

show

Project information

show

Source

show