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  Linking entropy at rest with the underlying structural connectivity in the healthy and lesioned brain

Saenger, V. M., Ponce-Alvarez, A., Adhikari, M., Hagmann, P., Deco, G., & Corbetta, M. (2018). Linking entropy at rest with the underlying structural connectivity in the healthy and lesioned brain. Cerebral Cortex, 28(8), 2948-2958. doi:10.1093/cercor/bhx176.

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Datensatz-Permalink: https://hdl.handle.net/21.11116/0000-0002-5E09-C Versions-Permalink: https://hdl.handle.net/21.11116/0000-0003-97B9-2
Genre: Zeitschriftenartikel

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 Urheber:
Saenger, Victor M. 1, Autor
Ponce-Alvarez, Adrián 1, Autor
Adhikari, Mohit 1, Autor
Hagmann, Patric 2, 3, Autor
Deco, Gustavo1, 4, 5, 6, Autor           
Corbetta, Maurizio 7, Autor
Affiliations:
1Department of Information and Communication Technologies, Center for Brain and Cognition, University Pompeu Fabra, Barcelona, Spain, ou_persistent22              
2Department of Radiology, Centre hospitalier universitaire vaudois, Lausanne, Switzerland, ou_persistent22              
3Signal Processing Laboratory 5, Swiss Federal Institute of Technology in Lausanne, Switzerland, ou_persistent22              
4Catalan Institution for Research and Advanced Studies (ICREA), University Pompeu Fabra, Barcelona, Spain, ou_persistent22              
5Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634551              
6School of Psychological Sciences, Monash University, Melbourne, Australia, ou_persistent22              
7Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA, ou_persistent22              

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Schlagwörter: Entropy; Information flow; Stroke; Structural connectivity; Whole-brain modeling
 Zusammenfassung: The brain is a network that mediates information processing through a wide range of states. The extent of state diversity is a reflection of the entropy of the network. Here we measured the entropy of brain regions (nodes) in empirical and modeled functional networks reconstructed from resting state fMRI to address the connection of entropy at rest with the underlying structure measured through diffusion spectrum imaging. Using 18 empirical and 18 modeled stroke networks, we also investigated the effect that focal lesions have on node entropy and information diffusion. Overall, positive correlations between node entropy and structure were observed, especially between node entropy and node strength in both empirical and modeled data. Although lesions were restricted to one hemisphere in all stroke patients, entropy reduction was not only present in nodes from the damaged hemisphere, but also in nodes from the contralesioned hemisphere, an effect replicated in modeled stroke networks. Globally, information diffusion was also affected in empirical and modeled strokes compared with healthy controls. This is the first study showing that artificial lesions affect local and global network aspects in very similar ways compared with empirical strokes, shedding new light into the functional nature of stroke.

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Sprache(n): eng - English
 Datum: 2017-05-222016-12-122017-07-132018-08-01
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: DOI: 10.1093/cercor/bhx176
PMID: 28981635
PMC: PMC6248473
 Art des Abschluß: -

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Projektname : The Dynamical and Structural Basis of Human Mind Complexity: Segregation and Integration of Information and Processing in the Brain / DYSTRUCTURE
Grant ID : 295129
Förderprogramm : Funding Programme 7
Förderorganisation : European Commission (EC)
Projektname : Spanish National Project Complexity of Brain States
Grant ID : PSI2016-75688-P
Förderprogramm : -
Förderorganisation : Spanish Research Agency (AEI) and the European Regional Development Fund (ERDF)
Projektname : Human Brain Project Specific Grant Agreement 1 / HBP SGA1
Grant ID : 720270
Förderprogramm : Horizon 2020
Förderorganisation : European Commission (EC)
Projektname : -
Grant ID : IJCI-2014–066
Förderprogramm : Juan de la Cierva fellowship
Förderorganisation : Spanish Ministry of Economy and Competitiveness
Projektname : -
Grant ID : PSI2013-42091-P
Förderprogramm : Research Personnel Training program
Förderorganisation : Spanish Ministry of Economy and Competitiveness

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Titel: Cerebral Cortex
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: New York, NY : Oxford University Press
Seiten: - Band / Heft: 28 (8) Artikelnummer: - Start- / Endseite: 2948 - 2958 Identifikator: ISSN: 1047-3211
CoNE: https://pure.mpg.de/cone/journals/resource/954925592440