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  Protein-Origami für Fortgeschrittene: Wie DnaK besser falten lernte

Schweizer, R., & Reinstein, J. (2012). Protein-Origami für Fortgeschrittene: Wie DnaK besser falten lernte. Biospektrum, 18(4), 372-375. doi:10.1007/s12268-012-0194-8.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-0024-1F43-2 Version Permalink: https://hdl.handle.net/11858/00-001M-0000-0024-1F44-F
Genre: Journal Article
Alternative Title : Protein-Origami für Fortgeschrittene: Wie DnaK besser falten lernte

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BIOspektrum_18_2012_372.pdf (Any fulltext), 329KB
 
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 Creators:
Schweizer, Regina1, Author           
Reinstein, Jochen1, Author           
Affiliations:
1Department of Biomolecular Mechanisms, Max Planck Institute for Medical Research, Max Planck Society, ou_1497700              

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 Abstract: The molecular chaperone DnaK was optimized by directed evolution for better refolding activity toward two substrates and the identified DnaK variants were analyzed for characteristic changes in their mechanism. Remarkably, none of the variants was modified in or in close proximity to the substrate binding pocket, although their substrate affinity was increased. These results indicate that improvement in chaperone activity for specific substrates does not necessarily decrease substrate promiscuity

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Language(s): deu - German
 Dates: 2012-06-01
 Publication Status: Issued
 Pages: -
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 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 664306
DOI: 10.1007/s12268-012-0194-8
URI: http://link.springer.com/article/10.1007%2Fs12268-012-0194-8
URI: http://link.springer.com/content/pdf/10.1007%2Fs12268-012-0194-8
Other: 7890
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Title: Biospektrum
Source Genre: Journal
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Publ. Info: Heidelberg, Germany : Spektrum Akademischer Verlag
Pages: - Volume / Issue: 18 (4) Sequence Number: - Start / End Page: 372 - 375 Identifier: ISSN: 0947-0867
CoNE: https://pure.mpg.de/cone/journals/resource/110978984077563