Deutsch
 
Hilfe Datenschutzhinweis Impressum
  DetailsucheBrowse

Datensatz

 
 
DownloadE-Mail
  Bridging the layers: towards integration of signal transduction, regulation and metabolism into mathematical models

Gonçalves, E., Bucher, J., Ryll, A., Niklas, J., Mauch, K., Klamt, S., et al. (2013). Bridging the layers: towards integration of signal transduction, regulation and metabolism into mathematical models. Molecular BioSystems, 9(7), 1576-1583. doi:10.1039/c3mb25489e.

Item is

Dateien

einblenden: Dateien
ausblenden: Dateien
:
1801321_ryll.pdf (Verlagsversion), 2MB
Name:
1801321_ryll.pdf
Beschreibung:
-
OA-Status:
Sichtbarkeit:
Öffentlich
MIME-Typ / Prüfsumme:
application/pdf / [MD5]
Technische Metadaten:
Copyright Datum:
-
Copyright Info:
This publication is with persmission of the rights owner freely accessible on MPG.PuRe (s. email SG/RSC vom 17.4.2015)
Lizenz:
-

Externe Referenzen

einblenden:

Urheber

einblenden:
ausblenden:
 Urheber:
Gonçalves, Emanuel1, Autor
Bucher, Joachim2, Autor
Ryll, Anke3, Autor           
Niklas, Jens2, Autor
Mauch, Klaus2, Autor
Klamt, Steffen3, Autor           
Rocha, Miguel4, Autor
Saez-Rodriguez, Julio1, Autor           
Affiliations:
1EMBL-EBI Bioinformatics Institut, Cambridge, UK , ou_persistent22              
2Insilico Biotechnology, Stuttgart, ou_persistent22              
3Analysis and Redesign of Biological Networks, Max Planck Institute for Dynamics of Complex Technical Systems, Max Planck Society, ou_1738139              
4Computer Science and Technology Centre - CCTC, School of Engineering, University of Minho, Portugal , ou_1753325              

Inhalt

einblenden:
ausblenden:
Schlagwörter: -
 Zusammenfassung: Mathematical modelling is increasingly becoming an indispensable tool for the study of cellular processes, allowing their analysis in a systematic and comprehensive manner. In the vast majority of the cases, models focus on specific subsystems, and in particular describe either metabolism, gene expression or signal transduction. Integrated models that are able to span and interconnect these layers are, by contrast, rare as their construction and analysis face multiple challenges. Such methods, however, would represent extremely useful tools to understand cell behaviour, with application in distinct fields of biological and medical research. In particular, they could be useful tools to study genotype–phenotype mappings, and the way they are affected by specific conditions or perturbations. Here, we review existing computational approaches that integrate signalling, gene regulation and/or metabolism. We describe existing challenges, available methods and point at potentially useful strategies. © Royal Society of Chemistry 2013 [accessed 2013 September 9th]

Details

einblenden:
ausblenden:
Sprache(n): eng - English
 Datum: 2013
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: DOI: 10.1039/c3mb25489e
 Art des Abschluß: -

Veranstaltung

einblenden:

Entscheidung

einblenden:

Projektinformation

einblenden:

Quelle 1

einblenden:
ausblenden:
Titel: Molecular BioSystems
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: -
Seiten: - Band / Heft: 9 (7) Artikelnummer: - Start- / Endseite: 1576 - 1583 Identifikator: ISSN: 1742-206X
CoNE: https://pure.mpg.de/cone/journals/resource/1000000000023020