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  Identification of Starmaker-Like in Medaka as a Putative Target Gene of Pax2 in the Otic Vesicle

Bajoghli, B., Ramialison, M., Aghaallaei, M., Czerny, T., & Wittbrodt, J. (2009). Identification of Starmaker-Like in Medaka as a Putative Target Gene of Pax2 in the Otic Vesicle. Developmental Dynamics, 238, 2860-2866.

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 Creators:
Bajoghli, Baubak1, Author           
Ramialison, Mirana, Author
Aghaallaei, Marges2, Author
Czerny, Thomas, Author
Wittbrodt, Joachim, Author
Affiliations:
1Department of Developmental Immunology, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, ou_2243647              
2Max Planck Society, ou_persistent13              

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Free keywords: Starmaker, otic vesicle, otoliths, medaka, zebrafish, Dspp
 Abstract: Otoliths in bony fishes are involved in the function of the ear in the senses of balance and hearing. In a large-scale random in situ hybridization screen of genes expressed in the medaka developing ear, we identified starmaker-like (stm-l) gene, a novel homologue of zebrafish starmaker and human dentine sialo-phosphoprotein (dspp) gene. Despite the absence of sequence similarity between these genes, here we describe their similar genomic structure and expression patterns hinting for a conserved function. In medaka fry, stm-l is expressed in various organs such as otoliths, teeth, gills, and kidney. Additionally, our results provide evidence that stm-l is a putative downstream target gene of Pax2 transcription factor and Pax2 itself has a promoting function in otolith formation.

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Language(s): eng - English
 Dates: 2009
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 446485
 Degree: -

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Title: Developmental Dynamics
  Alternative Title : Dev. Dyn.
Source Genre: Journal
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Publ. Info: -
Pages: - Volume / Issue: 238 Sequence Number: - Start / End Page: 2860 - 2866 Identifier: -