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  Heated gas bubbles enrich, crystallize, dry, phosphorylate and encapsulate prebiotic molecules

Morasch, M., Liu, J., Dirscherl, C. F., Laneselli, A., Kühnlein, A., Le Vay, K., et al. (2019). Heated gas bubbles enrich, crystallize, dry, phosphorylate and encapsulate prebiotic molecules. Nature Chemistry, 11(9), 779-788. doi:10.1038/s41557-019-0299-5.

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https://rdcu.be/ceiRy (Publisher version)
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 Creators:
Morasch, Matthias1, Author
Liu, Jonathan1, Author
Dirscherl, Christina F.1, Author
Laneselli, Alan1, Author
Kühnlein, Alexandra1, Author
Le Vay, Kristian2, Author              
Schwintek, Philipp1, Author
Islam, Saidul1, Author
Corpinot, Merina K.1, Author
Scheu, Bettina1, Author
Dingwell, Donald B.1, Author
Schwille, Petra3, Author              
Mutschler, Hannes2, Author              
Powner, Matthew W.1, Author
Mast, Christof B.1, Author
Braun, Dieter1, Author
Affiliations:
1external, ou_persistent22              
2Mutschler, Hannes / Biomimetic Systems, Max Planck Institute of Biochemistry, Max Planck Society, ou_2466697              
3Schwille, Petra / Cellular and Molecular Biophysics, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565169              

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Free keywords: PATTERN-FORMATION; SURFACE-TENSION; BOND FORMATION; WATER; DIFFUSION; SELECTION; POLYMERIZATION; ACCUMULATION; NUCLEOTIDES; CYCLES
 Abstract: Non-equilibrium conditions must have been crucial for the assembly of the first informational polymers of early life, by supporting their formation and continuous enrichment in a long-lasting environment. Here, we explore how gas bubbles in water subjected to a thermal gradient, a likely scenario within crustal mafic rocks on the early Earth, drive a complex, continuous enrichment of prebiotic molecules. RNA precursors, monomers, active ribozymes, oligonucleotides and lipids are shown to (1) cycle between dry and wet states, enabling the central step of RNA phosphorylation, (2) accumulate at the gas-water interface to drastically increase ribozymatic activity, (3) condense into hydrogels, (4) form pure crystals and (5) encapsulate into protecting vesicle aggregates that subsequently undergo fission. These effects occur within less than 30 min. The findings unite, in one location, the physical conditions that were crucial for the chemical emergence of biopolymers. They suggest that heated microbubbles could have hosted the first cycles of molecular evolution.

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Language(s): eng - English
 Dates: 2019
 Publication Status: Published in print
 Pages: 10
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: ISI: 000483307000008
DOI: 10.1038/s41557-019-0299-5
 Degree: -

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Title: Nature Chemistry
  Abbreviation : Nat. Chem.
Source Genre: Journal
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Publ. Info: London, UK : Nature Publishing Group
Pages: - Volume / Issue: 11 (9) Sequence Number: - Start / End Page: 779 - 788 Identifier: ISSN: 1755-4330
CoNE: https://pure.mpg.de/cone/journals/resource/1755-4330