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  The RSA complex targets Protein Phosphatase 2A to centrosomes and regulates mitotic spindle assembly in C. elegans

Schlaitz, A.-L., Srayko, M., Dammermann, A., Quintin, S., Wielsch, N., MacLeod, I., et al. (2007). The RSA complex targets Protein Phosphatase 2A to centrosomes and regulates mitotic spindle assembly in C. elegans. Cell, 128(1), 115-127. doi:10.1016/j.cell.2006.10.050.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-002C-E7B9-5 Version Permalink: https://hdl.handle.net/11858/00-001M-0000-002C-E7BA-3
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 Creators:
Schlaitz, Anne-Lore, Author
Srayko, Martin, Author
Dammermann, Alexander, Author
Quintin, Sophie, Author
Wielsch, Natalie1, Author           
MacLeod, Ian, Author
de Robillard, Quentin, Author
Zinke, Andrea, Author
Yates III, John R. , Author
Müller-Reichert, Thomas, Author
Shevchenko, Andrei, Author
Oegema, Karen, Author
Hyman, Anthony A., Author
Affiliations:
1External Organizations, ou_persistent22              

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 Abstract: Microtubule behavior changes during the cell cycle and during spindle assembly. However it remains unclear how these changes are regulated and coordinated. We describe a complex that targets the Protein Phosphatase 2A holoenzyme (PP2A) to centrosomes in C. elegans embryos. This complex includes RSA-1, a targeting subunit for PP2A, and RSA-2, a protein that binds and recruits RSA-1 to centrosomes. In contrast to the multiple functions of the PP2A catalytic subunit, RSA-1 and RSA-2 are specifically required for microtubule outgrowth from centrosomes and for spindle assembly. The centrosomally localized RSA-PP2A complex mediates these functions in part by regulating two critical mitotic effectors: the microtubule destabilizer KLP-7 and the C. elegans regulator of spindle assembly TPXL-1. Therefore, by recruiting the PP2A catalytic subunit to centrosomes, the RSA complex regulates a subset of PP2A functions in order to coordinate microtubule outgrowth from centrosomes and microtubule stability in the forming mitotic spindle.

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 Dates: 2007
 Publication Status: Issued
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 Identifiers: Other: EXT478
DOI: 10.1016/j.cell.2006.10.050
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Title: Cell
Source Genre: Journal
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Publ. Info: Cambridge, Mass. : Cell Press
Pages: - Volume / Issue: 128 (1) Sequence Number: - Start / End Page: 115 - 127 Identifier: ISSN: 0092-8674
CoNE: https://pure.mpg.de/cone/journals/resource/954925463183