English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
Add to Basket
 Local TagsRelease HistoryDetailsSummary
  Host genome integration and giant virus-induced reactivation of the virophage mavirus

Fischer, M. G., & Hackl, T. (2016). Host genome integration and giant virus-induced reactivation of the virophage mavirus. Nature, 540(7632), 288-291. doi:10.1038/nature20593.

Item is

 

show all hide all

Basic

show hide
Item Permalink: https://hdl.handle.net/11858/00-001M-0000-002C-1A54-C Version Permalink: https://hdl.handle.net/11858/00-001M-0000-002C-1BEB-0
Genre: Journal Article

Files

show Files
hide Files
:
Nature_540_2016_288.pdf (Any fulltext), 4MB
 
File Permalink:
-
Name:
Nature_540_2016_288.pdf
Description:
-
OA-Status:
Visibility:
Restricted (Max Planck Institute for Medical Research, MHMF; )
MIME-Type / Checksum:
application/pdf
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-
:
Nature_540_2016_288_Suppl1.xlsx (Supplementary material), 54KB
 
File Permalink:
-
Name:
Nature_540_2016_288_Suppl1.xlsx
Description:
-
OA-Status:
Visibility:
Restricted (Max Planck Institute for Medical Research, MHMF; )
MIME-Type / Checksum:
application/vnd.openxmlformats-officedocument.spreadsheetml.sheet
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-
:
Nature_540_2016_288_Suppl2.xlsx (Supplementary material), 54KB
 
File Permalink:
-
Name:
Nature_540_2016_288_Suppl2.xlsx
Description:
-
OA-Status:
Visibility:
Restricted (Max Planck Institute for Medical Research, MHMF; )
MIME-Type / Checksum:
application/vnd.openxmlformats-officedocument.spreadsheetml.sheet
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-
:
Nature_540_2016_288_Suppl3.xlsx (Supplementary material), 59KB
 
File Permalink:
-
Name:
Nature_540_2016_288_Suppl3.xlsx
Description:
-
OA-Status:
Visibility:
Restricted (Max Planck Institute for Medical Research, MHMF; )
MIME-Type / Checksum:
application/vnd.openxmlformats-officedocument.spreadsheetml.sheet
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-
:
Nature_540_2016_288_Suppl4.xlsx (Supplementary material), 13KB
 
File Permalink:
-
Name:
Nature_540_2016_288_Suppl4.xlsx
Description:
-
OA-Status:
Visibility:
Restricted (Max Planck Institute for Medical Research, MHMF; )
MIME-Type / Checksum:
application/vnd.openxmlformats-officedocument.spreadsheetml.sheet
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-
:
Nature_540_2016_288_Suppl5.xlsx (Supplementary material), 24KB
 
File Permalink:
-
Name:
Nature_540_2016_288_Suppl5.xlsx
Description:
-
OA-Status:
Visibility:
Restricted (Max Planck Institute for Medical Research, MHMF; )
MIME-Type / Checksum:
application/vnd.openxmlformats-officedocument.spreadsheetml.sheet
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-

Locators

show
hide
Locator:
http://www.nature.com/nature/journal/v540/n7632/pdf/nature20593.pdf (Any fulltext)
Description:
-
OA-Status:
Locator:
https://dx.doi.org/10.1038/nature20593 (Any fulltext)
Description:
-
OA-Status:

Creators

show
hide
 Creators:
Fischer, Matthias G.1, Author           
Hackl, Thomas1, Author           
Affiliations:
1Department of Biomolecular Mechanisms, Max Planck Institute for Medical Research, Max Planck Society, ou_1497700              

Content

show
hide
Free keywords: Coevolution ; Virus-host interactions
 Abstract: Endogenous viral elements are increasingly found in eukaryotic genomes1, yet little is known about their origins, dynamics, or function. Here we provide a compelling example of a DNA virus that readily integrates into a eukaryotic genome where it acts as an inducible antiviral defence system. We found that the virophage mavirus2, a parasite of the giant Cafeteria roenbergensis virus (CroV)3, integrates at multiple sites within the nuclear genome of the marine protozoan Cafeteria roenbergensis4. The endogenous mavirus is structurally and genetically similar to eukaryotic DNA transposons and endogenous viruses of the Maverick/Polinton family5, 6, 7. Provirophage genes are not constitutively expressed, but are specifically activated by superinfection with CroV, which induces the production of infectious mavirus particles. Virophages can inhibit the replication of mimivirus-like giant viruses and an anti-viral protective effect of provirophages on their hosts has been hypothesized2, 8. We find that provirophage-carrying cells are not directly protected from CroV; however, lysis of these cells releases infectious mavirus particles that are then able to suppress CroV replication and enhance host survival during subsequent rounds of infection. The microbial host–parasite interaction described here involves an altruistic aspect and suggests that giant-virus-induced activation of provirophages might be ecologically relevant in natural protist populations.

Details

show
hide
Language(s): eng - English
 Dates: 2016-06-082016-11-022016-12-072016-12-08
 Publication Status: Issued
 Pages: 4
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1038/nature20593
URI: http://www.nature.com/nature/journal/v540/n7632/full/nature20593.html
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Nature
  Abbreviation : Nature
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: London : Nature Publishing Group
Pages: - Volume / Issue: 540 (7632) Sequence Number: - Start / End Page: 288 - 291 Identifier: ISSN: 0028-0836
CoNE: https://pure.mpg.de/cone/journals/resource/954925427238