English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Spatio-temporal indications of sub-cortical involvement in leftward bias of spatial attention

Okon-Singer, H., Podlipsky, I., Siman-Tov, T., Ben-Simon, E., Zhdanov, A., Neufeld, M. Y., et al. (2011). Spatio-temporal indications of sub-cortical involvement in leftward bias of spatial attention. Neuroimage, 54(4), 3010-3020. doi:10.1016/j.neuroimage.2010.10.078.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0012-04A3-6 Version Permalink: http://hdl.handle.net/21.11116/0000-0002-B352-7
Genre: Journal Article

Files

show Files
hide Files
:
Okon-Singer_et_al_NeuroImage_2011.pdf (Postprint), 803KB
 
File Permalink:
-
Name:
Okon-Singer_et_al_NeuroImage_2011.pdf
Description:
-
Visibility:
Restricted (Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig; )
MIME-Type / Checksum:
application/pdf
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-

Locators

show

Creators

show
hide
 Creators:
Okon-Singer, Hadas1, 2, Author              
Podlipsky, Ilana1, Author
Siman-Tov, Tali 2, Author
Ben-Simon, Eti1, 3, Author
Zhdanov, Andrey1, Author
Neufeld, Miri Y.3, 4, Author
Hendler, Talma1, 3, Author
Affiliations:
1Functional Brain Center, Wohl Institute for Advanced Imaging, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel, ou_persistent22              
2Cognitive Neurology Unit, Rambam Health Care Campus, Haifa, Israel, ou_persistent22              
3Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel, ou_persistent22              
4EEG and Epilepsy Unit, Department of Neurology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel, ou_persistent22              

Content

show
hide
Free keywords: Cross-correlation, Dynamic causal modeling (DCM), Inferior parietal sulcus, Inter-hemispheric transfer time, Pulvinar, Simultaneous ERP–fMRI
 Abstract: A leftward bias is well known in humans and animals, and commonly related to the right hemisphere dominance for spatial attention. Our previous fMRI study suggested that this bias is mediated by faster conduction from the right to left parietal cortices, than the reverse (Siman-Tov et al., 2007). However, the limited temporal resolution of fMRI and evidence on the critical involvement of sub-cortical regions in orienting of spatial attention suggested further investigation of the leftward bias using multi-scale measurement. In this simultaneous EEG–fMRI study, healthy participants were presented with face pictures in either the right or left visual fields while performing a central fixation task. Temporo-occipital event related potentials, time-locked to the stimulus onset, showed an association between faster conduction from the right to the left hemisphere and higher fMRI activation in the left pulvinar nucleus following left visual field stimulation. This combined-modal finding provides original evidence of the involvement of sub-cortical central attention-related regions in the leftward bias. This assertion was further strengthened by a DCM analysis designated at cortical (i.e., inferior parietal sulcus; IPS) and sub-cortical (pulvinar nucleus) attention related nodes that revealed: 1. Stronger inter-hemispheric connections from the right to left than vice versa, already at the pulvinar level. 2. Stronger connections within the right than the left hemisphere, from the pulvinar to the IPS. This multi-level neural superiority can guide future efforts in alleviating attention deficits by focusing on improving network connectivity.

Details

show
hide
Language(s): eng - English
 Dates: 2010-10-252010-06-212010-10-272010-11-052011-02-01
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1016/j.neuroimage.2010.10.078
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Neuroimage
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Orlando, FL : Academic Press
Pages: - Volume / Issue: 54 (4) Sequence Number: - Start / End Page: 3010 - 3020 Identifier: ISSN: 1053-8119
CoNE: /journals/resource/954922650166