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  High resolution magnetic susceptibility mapping of the substantia nigra in Parkinson's disease

Lotfipour, A. K., Wharton, S., Schwarz, S. T., Gontu, V., Schäfer, A., Peters, A. M., et al. (2012). High resolution magnetic susceptibility mapping of the substantia nigra in Parkinson's disease. Journal of Magnetic Resonance Imaging, 35(1), 48-55. doi:10.1002/jmri.22752.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0012-06CF-3 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-CC69-2
Genre: Journal Article

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Lotfipour_2012_High.pdf (Publisher version), 427KB
 
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 Creators:
Lotfipour, Ashley K.1, Author
Wharton, Samuel1, Author
Schwarz, Stefan T.2, Author
Gontu, V.2, Author
Schäfer, Andreas1, Author              
Peters, Andrew M.1, Author
Bowtell, Richard W.1, Author
Auer, Dorothee P.2, Author
Gowland, Penny A.1, Author
Bajaj, Nin P.S.3, Author
Affiliations:
1Sir Peter Mansfield Magnetic Resonance Centre, University of Nottingham, United Kingdom, ou_persistent22              
2Academic Radiology, School of Clinical Sciences, University of Nottingham, United Kingdom, ou_persistent22              
3Department of Neurology, Nottingham University Hospital, United Kingdom, ou_persistent22              

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Free keywords: Susceptibility; Substantia nigra; Pars compacta; Iron; Parkinson's disease
 Abstract: Purpose: To determine if tissue magnetic susceptibility is a more direct marker of tissue iron content than other MR markers of iron. This study presents the first quantitative, in vivo measurements of the susceptibility of the substantia nigra in patients with Parkinson's disease. Materials and Methods: Nine patients and 11 controls were studied at 7 Tesla. Susceptibility maps were created by inverting the filtered phase maps associated with T2* weighted images. Results: On average, patients showed an increase in susceptibility of the pars compacta compared with controls, which correlates with the predicted increase in brain iron in Parkinson's disease. A rostral–caudal gradient in susceptibility was also observed in controls and patients. Conclusion: Susceptibility mapping may provide a new tool for studying the development of Parkinson's disease.

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Language(s): eng - English
 Dates: 2011-07-212011-10-102012-01-01
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1002/jmri.22752
PMID: 21987471
Other: Epub 2011
 Degree: -

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Title: Journal of Magnetic Resonance Imaging
Source Genre: Journal
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Publ. Info: Chicago, IL : Society for Magnetic Resonance Imaging
Pages: - Volume / Issue: 35 (1) Sequence Number: - Start / End Page: 48 - 55 Identifier: ISSN: 1053-1807
CoNE: https://pure.mpg.de/cone/journals/resource/954925594512