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  Structural studies of the hypothalamus and its nuclei in mood disorders

Schindler, S., Geyer, S., Strauß, M., Anwander, A., Hegerl, U., Turner, R., et al. (2012). Structural studies of the hypothalamus and its nuclei in mood disorders. Psychiatry Research: Neuroimaging, 201(1), 1-9. doi:10.1016/j.pscychresns.2011.06.005.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0012-0FAE-9 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-B036-9
Genre: Journal Article

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Schindler_2012_Structural.pdf (Publisher version), 242KB
 
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 Creators:
Schindler, Stephanie1, Author              
Geyer, Stefan2, Author              
Strauß, Maria1, Author
Anwander, Alfred3, Author              
Hegerl, Ulrich1, Author
Turner, Robert2, Author              
Schönknecht, Peter1, Author
Affiliations:
1Department of Psychiatry and Psychotherapy, University Hospital Leipzig, Germany, ou_persistent22              
2Department Neurophysics, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634550              
3Methods and Development Unit Cortical Networks and Cognitive Functions, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634557              

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Free keywords: Depression; Bipolar disorder; Volumetry; MRI
 Abstract: A large body of evidence indicates that the hypothalamus is involved in pathogenetic mechanisms of mood disorders. It has been suggested that functional abnormalities of the hypothalamus are associated with structural hypothalamic changes. Structural neuroimaging allows in vivo investigation of the hypothalamus that may shed light on the underlying pathogenetic mechanisms of unipolar and bipolar disorder. Clearly, the detection of subtle structural cerebral changes depends on the limitations of the neuroimaging technique used. Making a comprehensive database search, we reviewed the literature on hypothalamic macrostructure in affective disorders, addressing the specific question of what structural magnetic resonance imaging might be expected to show. Studies with convincing methodology, although rare, suggest a global volume decrease in the hypothalamus in affective disorders, a decrease which is not shown by the two specific nuclei investigated, the paraventricular and supraoptic nuclei. We discuss the implications of these findings and provide directions for future research.

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Language(s): eng - English
 Dates: 2011-06-012010-10-132011-06-112012-01-272012-01-30
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1016/j.pscychresns.2011.06.005
PMID: 22285717
Other: Epub 2012
 Degree: -

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Title: Psychiatry Research: Neuroimaging
  Other : Psychiatry Res. Neuroimaging
Source Genre: Journal
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Publ. Info: Elsevier
Pages: - Volume / Issue: 201 (1) Sequence Number: - Start / End Page: 1 - 9 Identifier: ISSN: 0925-4927
CoNE: https://pure.mpg.de/cone/journals/resource/954925566740