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  Neural correlates of the volitional regulation of the desire for food

Hollmann, M., Hellrung, L., Pleger, B., Schlögl, H., Kabisch, S., Stumvoll, M., et al. (2012). Neural correlates of the volitional regulation of the desire for food. International Journal of Obesity, 36(5), 648-655. doi:10.1038/ijo.2011.125.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0012-0FB4-A Version Permalink: http://hdl.handle.net/21.11116/0000-0003-B0EA-E
Genre: Journal Article

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Hollmann_2012_Neural.pdf (Publisher version), 371KB
 
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 Creators:
Hollmann, Maurice1, Author              
Hellrung, Lydia1, Author              
Pleger, Burkhard1, 2, 3, 4, Author              
Schlögl, Haiko1, 5, Author              
Kabisch, Stefan1, 5, Author              
Stumvoll, Michael2, 5, Author
Villringer, Arno1, 2, 3, 4, Author              
Horstmann, Annette1, 2, Author              
Affiliations:
1Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
2Integrated Research and Treatment Center Adiposity Diseases, University of Leipzig, Germany, ou_persistent22              
3Clinic for Cognitive Neurology, University of Leipzig, Germany, ou_persistent22              
4Berlin School of Mind and Brain, Humboldt University Berlin, Germany, ou_persistent22              
5Department of Internal Medicine, Clinic for Endocrinology and Nephrology, University Hospital Leipzig, Germany, ou_persistent22              

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Free keywords: Eating behavior; Food desire; Cognitive control; Functional MRI; Craving
 Abstract: Objective: In this study, we investigate the brain mechanisms of the conscious regulation of the desire for food using functional magnetic resonance imaging. Further, we examine associations between hemodynamic responses and participants’ cognitive restraint of eating (CRE), as well as their susceptibility to uncontrolled eating. Subjects: Seventeen non-vegetarian, right-handed, female Caucasian participants (age: 20–30 years, mean 25.3 years±3.1 s.d.; BMI: 20.2–31.2 kg m−2, mean 25.1±3.5 s.d.). Measurements: During scanning, our participants viewed pictures of food items they had pre-rated according to tastiness and healthiness. Participants were either allowed to admit to the desire for the food (ADMIT) or they were instructed to downregulate their desire using a cognitive reappraisal strategy, that is, thinking of negative long-term health-related and social consequences (REGULATE). Results: Comparing the hemodynamic responses of the REGULATE with the ADMIT condition, we observed robust activation in the dorsolateral prefrontal cortex (DLPFC), the pre-supplementary motor area, the inferior frontal gyrus (IFG), the dorsal striatum (DS), the bilateral orbitofrontal cortex (OFC), the anterior insula and the temporo-parietal junction (TPJ). Activation in the DLPFC and the DS strongly correlated with the degree of dietary restraint under both conditions. Conclusion: Cortical activation in the DLPFC, the pre-supplementary motor area and the inferior frontal gyrus (IFG) are known to underpin top-down control, inhibition of learned associations and pre-potent responses. The observed hemodynamic responses in the lateral OFC, the DS, the anterior insula and the TPJ support the notion of reward valuation and integration, interoceptive awareness, and self-reflection as key processes during active regulation of desire for food. In conclusion, an active reappraisal of unhealthy food recruits the brain's valuation system in combination with prefrontal cognitive control areas associated with response inhibition. The correlations between brain responses and CRE suggest that individuals with increased cognitive restraint show an automatic predisposition to regulate the hedonic aspects of food stimuli. This cognitive control might be necessary to counterbalance a lack of homeostatic mechanisms.

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Language(s): eng - English
 Dates: 2011-05-122011-06-282012-05
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1038/ijo.2011.125
PMID: 21712804
Other: Epub 2011
 Degree: -

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Title: International Journal of Obesity
  Other : International Journal of Obesity
Source Genre: Journal
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Publ. Info: -
Pages: - Volume / Issue: 36 (5) Sequence Number: - Start / End Page: 648 - 655 Identifier: ISSN: 0307-0565
CoNE: https://pure.mpg.de/cone/journals/resource/954925515513_1