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  Serotonin transporter occupancy and the functional neuroanatomic effects of citalopram in geriatric depression

Smith, G. S., Kahn, A., Sacher, J., Rusjan, P., van Eimeren, T., Flint, A., et al. (2011). Serotonin transporter occupancy and the functional neuroanatomic effects of citalopram in geriatric depression. The American Journal of Geriatric Psychiatry, 19(12), 1016-1025. doi:10.1097/JGP.0b013e318227f83f.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0012-1198-8 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-CF9D-4
Genre: Journal Article

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 Creators:
Smith, Gwenn S.1, 2, 3, Author
Kahn, Alan2, 3, Author
Sacher, Julia2, 3, 4, 5, Author              
Rusjan, Pablo2, Author
van Eimeren, Thilo6, Author
Flint, Alastair3, Author
Wilson, Alan A.2, 3, Author
Affiliations:
1Division of Geriatric Psychiatry, University of Toronto, ON, Canada, ou_persistent22              
2Centre for Addiction and Mental Health, University of Toronto, ON, Canada, ou_persistent22              
3Department of Psychiatry, University Health Network, University of Toronto, ON, Canada, ou_persistent22              
4Clinic for Cognitive Neurology, University of Leipzig, Germany, ou_persistent22              
5Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
6Department of Neurology, University Health Network, University of Toronto, ON, Canada, ou_persistent22              

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Free keywords: Aging; Citalopram; Depression; Glucose metabolism; Positron emission tomography (PET); Selective serotonin reuptake inhibitors; Serotonin; Serotonin transporter
 Abstract: Objectives The functional neuroanatomic changes associated with selective serotonin reuptake inhibitor (SSRI) treatment have been the focus of positron emission tomography (PET) studies of cerebral glucose metabolism in geriatric depression. Design To evaluate the underlying neurochemical mechanisms, both cerebral glucose metabolism and serotonin transporter (SERT) availability were measured before and during treatment with the SSRI, citalopram. It was hypothesized that SERT occupancy would be observed in cortical and limbic brain regions that have shown metabolic effects, as well as striatal and thalamic regions that have been implicated in prior studies in midlife patients. Setting Psychiatric outpatient clinic. Participants Seven depressed patients who met Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition criteria for current major depressive episode were enrolled. Intervention Patients underwent a 12-week open-label trial of the SSRI, citalopram. Measurements Patients underwent high-resolution research tomography PET scans to measure changes in cerebral glucose metabolism and SERT occupancy by citalopram treatment (after 8–10 weeks of treatment). Results Three different tracer kinetic models were applied to the [11C]-DASB region-of-interest data and yielded similar results of an average of greater than 70% SERT occupancy in the striatum and thalamus during citalopram treatment. Voxel-wise analyses showed significant SERT occupancy in these regions, as well as cortical (e.g., anterior cingulate, superior and middle frontal, precuneus, and limbic (parahippocampal gyrus) areas that also showed reductions in glucose metabolism. Conclusion The findings suggest that cortical and limbic SERT occupancy may be an underlying mechanism for the regional cerebral metabolic effects of citalopram in geriatric depression.

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Language(s): eng - English
 Dates: 2011-03-292013-01-282011-12
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1097/JGP.0b013e318227f83f
PMID: 21841458
PMC: PMC3968900
 Degree: -

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Title: The American Journal of Geriatric Psychiatry
  Abbreviation : Am J Geriatr Psychiatry
Source Genre: Journal
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Publ. Info: Washington, DC : American Psychiatry Press
Pages: - Volume / Issue: 19 (12) Sequence Number: - Start / End Page: 1016 - 1025 Identifier: ISSN: 1064-7481
CoNE: https://pure.mpg.de/cone/journals/resource/1064-7481