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  Cognitive outcome in adults after bacterial meningitis

Hoogman, M., Weisfelt, M., van de Beek, D., de Gans, J., & Schmand, B. (2007). Cognitive outcome in adults after bacterial meningitis. Journal of Neurology, Neurosurgery & Psychiatry, 78, 1092-1096. doi:10.1136/jnnp.2006.110023.

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Hoogman_2007_Cognitive_Outcome_J Neurol Neurosurg Psychiatry.pdf (Publisher version), 172KB
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Hoogman_2007_Cognitive_Outcome_J Neurol Neurosurg Psychiatry.pdf
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Hoogman, Martine1, Author           
Weisfelt, Martijn1, Author
van de Beek, Diederik1, Author
de Gans, Jan1, Author
Schmand, Ben1, Author
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1Department of Neurology, Centre of Infection and Immunity Amsterdam (CINIMA), Academic Medical Centre, Amsterdam, the Netherlands, ou_persistent22              

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 Abstract: Objective: To evaluate cognitive outcome in adult survivors of bacterial meningitis. Methods: Data from three prospective multicentre studies were pooled and reanalysed, involving 155 adults surviving bacterial meningitis (79 after pneumococcal and 76 after meningococcal meningitis) and 72 healthy controls. Results: Cognitive impairment was found in 32% of patients and this proportion was similar for survivors of pneumococcal and meningococcal meningitis. Survivors of pneumococcal meningitis performed worse on memory tasks (p<0.001) and tended to be cognitively slower than survivors of meningococcal meningitis (p = 0.08). We found a diffuse pattern of cognitive impairment in which cognitive speed played the most important role. Cognitive performance was not related to time since meningitis; however, there was a positive association between time since meningitis and self-reported physical impairment (p<0.01). The frequency of cognitive impairment and the numbers of abnormal test results for patients with and without adjunctive dexamethasone were similar. Conclusions: Adult survivors of bacterial meningitis are at risk of cognitive impairment, which consists mainly of cognitive slowness. The loss of cognitive speed is stable over time after bacterial meningitis; however, there is a significant improvement in subjective physical impairment in the years after bacterial meningitis. The use of dexamethasone was not associated with cognitive impairment.

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Language(s): eng - English
 Dates: 2007
 Publication Status: Issued
 Pages: -
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 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1136/jnnp.2006.110023
PMID: 17353256
PMC: PMC2117539
 Degree: -

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Title: Journal of Neurology, Neurosurgery & Psychiatry
Source Genre: Journal
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Publ. Info: London : British Medical Association
Pages: - Volume / Issue: 78 Sequence Number: - Start / End Page: 1092 - 1096 Identifier: ISSN: 0022-3050
CoNE: https://pure.mpg.de/cone/journals/resource/111085522793000