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  Neuroimaging-Verfahren in der Adipositasforschung [Neuroimaging in obesity research]

Kabisch, S., Schlögl, H., Villringer, A., & Stumvoll, M. (2011). Neuroimaging-Verfahren in der Adipositasforschung [Neuroimaging in obesity research]. Journal für Klinische Endokrinologie und Stoffwechsel, 4(3), 32-39.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0012-1441-1 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002C-1963-1
Genre: Journal Article

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Kabisch et al. - Neuroimaging in der Adipositasforschung.pdf (Preprint), 3MB
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 Creators:
Kabisch, Stefan1, Author
Schlögl, Haiko1, Author              
Villringer, Arno2, Author              
Stumvoll, Michael1, Author
Affiliations:
1Universität Leipzig, External Organizations, Leipzig, Germany, ou_452891              
2Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, Leipzig, Germany, ou_634549              

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Free keywords: Obesity; Neuroimaging; Functional magnetic resonance tomography; voxel-based morphometry; positron emission tomography
 Abstract: Neuroimaging Technologies in Obesity Research. Neurological correlates of obesity have been extensively discussed and investigated over the last few years. Use of neuroima ging technology provides novel ap- proaches to obesity research. Among these, magnetic resonance imaging (MRI) and positron emission tomography (PET) appear to be most promising. Due to the great variability of con- founding factors on brain development many selection criteria have to be fulfi lled in order to assure the reliability of a neuroimaging study. The number of highly capable MRI and PET in- vestigation centers is increasing, especially in large urban areas where highly characterized cohorts of subjects can be recruited. Recent in- vestigations have shown that the human brain receives and distributes homeostatic and he- donic impulses to regulate eating behavior. Both hunger and appetite are distinct aspects of the drive to eat originating in different brain areas, yet subject to a common regulating center. The responsible areas appear to be structurally and functionally altered in obesity, including chang- es in the reward system. Women and men (both lean and obese) seem to respond differentially to homeostatic and hedonic stimuli for hunger and satiety. The “hun ger networks” are affect- ed by genetic, biochemical, hormonal, neuronal, and other factors. For example ghrelin, peptide YY, and leptin are claimed to be endocrine sig- nals from the gastro intes ti nal tract and adipose tissue not only regulating metabolic activity and nutrient distribution but also possessing central nervous effects. These hormones act as short- time or long-time modulators of specifi c brain areas with homeostatic or hedonic power on food evaluation and eating behavior. Know- ing the interactions of certain brain regions in the regulation of hunger/appetite and satiety/ satiation will allow for the development of new therapeutic agents against obesity.

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Language(s): deu - German
 Dates: 2010-11-202011-04-06
 Publication Status: Published online
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Title: Journal für Klinische Endokrinologie und Stoffwechsel
  Other : Austrian Journal of Clinical Endocrinology and Metabolism
Source Genre: Journal
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Publ. Info: Gablitz : Krause & Pachernegg
Pages: - Volume / Issue: 4 (3) Sequence Number: - Start / End Page: 32 - 39 Identifier: ISSN: 1998-7773
CoNE: /journals/resource/1998-7773