English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  MRI analysis in temporal lobe epilepsy: Cortical thinning and white matter disruptions are related to side of seizure onset

Kemmotsu, N., Girard, H. M., Bernhardt, B. C., Bonilha, L., Lin, J. J., Tecoma, E. S., et al. (2011). MRI analysis in temporal lobe epilepsy: Cortical thinning and white matter disruptions are related to side of seizure onset. Epilepsia, 52(12), 2257-2266. doi:10.1111/j.1528-1167.2011.03278.x.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0012-14E7-B Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002B-C5CA-F
Genre: Journal Article

Files

show Files

Locators

show

Creators

show
hide
 Creators:
Kemmotsu, Nobuko1, 2, Author
Girard, Holly M.2, Author
Bernhardt, Boris C. 3, 4, Author              
Bonilha, Leonardo5, Author
Lin, Jack J.6, Author
Tecoma, Evelyn S.7, Author
Iragui, Vicente J.7, Author
Hagler, Donald J. Jr.2, 8, Author
Halgren, Eric2, 8, Author
McDonald, Carrie R.1, 2, Author
Affiliations:
1Department of Psychiatry, University of California San Diego, La Jolla, CA, USA, ou_persistent22              
2Multimodal Imaging Laboratory, University of California San Diego, La Jolla, CA, USA, ou_persistent22              
3Neuroimaging of Epilepsy Laboratory, Montreal Neurological Institute and Hospital, McGill University, Montréal, QC, Canada, ou_persistent22              
4Department Social Neuroscience, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634552              
5Division of Neurology, Medical University of South Carolina, Charleston, SC, USA, ou_persistent22              
6Department of Neurology, University of California, Irvine, CA, USA, ou_persistent22              
7Department of Neurosciences, University of California San Diego, La Jolla, CA, USA, ou_persistent22              
8Department of Radiology, University of California San Diego, La Jolla, CA, USA, ou_persistent22              

Content

show
hide
Free keywords: Epilepsy; MRI; Diffusion tensor imaging; Cortical thickness
 Abstract: Purpose: Past studies have reported more widespread structural brain abnormalities in patients with left compared to right temporal lobe epilepsy (TLE), but the profile of these differences remain unknown. This study investigated the relationship between cortical thinning, white matter compromise, epilepsy variables and the side of seizure onset, in patients with TLE. Methods: We performed diffusion tensor imaging tractography and cortical thickness analyses of 18 patients with left TLE (LTLE), 18 patients with right TLE (RTLE), and 36 controls. We investigated the relationship between brain structural abnormalities, side of seizure onset, age of seizure onset, and disease duration. Key findings: TLE groups displayed cortical thinning and white matter compromise, predominately on the side ipsilateral to the seizure onset. Relative to RTLE, patients with LTLE showed more widespread abnormalities, particularly in white matter fiber tracts. Greater compromise in white matter integrity was associated with earlier age of seizure onset, while cortical thinning was marginally associated with disease duration. Significance: These data support previous findings of LTLE showing greater structural compromise than RTLE, and suggest that mechanisms may not be uniform for gray and white matter compromise in patients with LTLE and RTLE. These results may indicate that LTLE is different than RTLE, possibly due to greater vulnerability of the left hemisphere to early injury and the progressive effects of seizures.

Details

show
hide
Language(s): eng - English
 Dates: 2011-08-122011-10-052011-12-12
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: DOI: 10.1111/j.1528-1167.2011.03278.x
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Epilepsia
  Other : Epilepsia
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Malden : Wiley-Blackwell
Pages: - Volume / Issue: 52 (12) Sequence Number: - Start / End Page: 2257 - 2266 Identifier: ISSN: 0013-9580
CoNE: https://pure.mpg.de/cone/journals/resource/954925397463