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  Humoral autoimmunity in multiple sclerosis

Meinl, E., Derfuss, T., Krumbholz, M., Pröbstel, A. K., & Hohlfeld, R. (2011). Humoral autoimmunity in multiple sclerosis. Journal of the Neurological Sciences, 306(1-2), 180-182.

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 Creators:
Meinl, E.1, Author              
Derfuss, T.1, Author              
Krumbholz, M.1, Author              
Pröbstel, A. K.1, Author              
Hohlfeld, R.1, Author              
Affiliations:
1Department: Neuroimmunology / Wekerle, MPI of Neurobiology, Max Planck Society, ou_1113547              

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Free keywords: Neuroimmunology; Multiple sclerosis; Node of Ranvier; BAFF
 Abstract: The important role of B cells and autoantibodies in the pathogenesis of MS is increasingly appreciated. The recruitment and maintenance of B cells and plasma cells in MS lesions is presumably based on local production of lymphoid chemokines and B cell activation factor of the TNF family (BAFF). The failure of the clinical trial with Atacicept targeting BAFF and its relative APRIL was a great surprise and cannot readily be explained. A role for BAFF in CNS physiology, e.g. via targeting of the Nogo-66 receptor might have to be considered. The identification of patient subgroups based on autoantibodies is a future challenge. Currently patients with neuromyelitis optica (NMO) can be identified by antibodies to aquaporin 4 and about a third of children with acquired demyelinating diseases have antibodies against conformationally correct MOG, while such antibodies are hardly found in adult MS patients. Searching for new targets of the autoimmune response in adult MS patients, we have identified two axo-glial proteins focused around the node of Ranvier, namely neurofascin and contactin-2/TAG-1. Testing the functional relevance of such an autoimmune response in animal models revealed that antibodies to neurofascin may induce axonal injury and that T cells specific for contactin-2/1-AG-1 mediate preferentially gray matter injury. (C) 2010 Elsevier B.V. All rights reserved.

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Language(s): eng - English
 Dates: 2011-07-15
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 570753
ISI: 000292664200034
 Degree: -

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Title: Journal of the Neurological Sciences
  Alternative Title : J. Neurol. Sci.
Source Genre: Journal
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Publ. Info: AMSTERDAM : ELSEVIER SCIENCE BV
Pages: - Volume / Issue: 306 (1-2) Sequence Number: - Start / End Page: 180 - 182 Identifier: ISSN: 0022-510X