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  Microtubule Stabilization Reduces Scarring and Causes Axon Regeneration After Spinal Cord Injury

Hellal, F., Hurtado, A., Ruschel, J., Flynn, K. C., Laskowski, C. J., Umlauf, M., et al. (2011). Microtubule Stabilization Reduces Scarring and Causes Axon Regeneration After Spinal Cord Injury. Science, 331(6019), 928-931.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-0012-1F06-4 Version Permalink: https://hdl.handle.net/11858/00-001M-0000-0012-1F07-2
Genre: Journal Article

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 Creators:
Hellal, F.1, Author           
Hurtado, A.2, Author
Ruschel, J.1, Author           
Flynn, K. C.1, Author           
Laskowski, C. J.1, Author           
Umlauf, M.3, Author
Kapitein, L. C.2, Author
Strikis, D.2, Author
Lemmon, V.2, Author
Bixby, J.2, Author
Hoogenraad, C. C.2, Author
Bradke, F.1, Author           
Affiliations:
1Max Planck Research Group: Axonal Growth and Regeneration / Bradke, MPI of Neurobiology, Max Planck Society, ou_1113553              
2[Hurtado, Andres] Johns Hopkins Univ, Hugo W Moser Res Inst Kennedy Krieger, Int Ctr Spinal Cord Injury, Dept Neurol, Baltimore, MD 21205 USA.; [Kapitein, Lukas C.; Hoogenraad, Casper C.] Erasmus MC, Dept Neurosci, NL-3000 CA Rotterdam, Netherlands.; [Kapitein, Lukas C.; Hoogenraad, Casper C.] Univ Utrecht, Fac Sci, NL-3584 CH Utrecht, Netherlands.; [Strikis, Dinara; Lemmon, Vance; Bixby, John] Univ Miami, Miller Sch Med, Miami Project Cure Paralysis, Miami, FL 33136 USA., ou_persistent22              
3Max Planck Society, ou_persistent13              

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 Abstract: Hypertrophic scarring and poor intrinsic axon growth capacity constitute major obstacles for spinal cord repair. These processes are tightly regulated by microtubule dynamics. Here, moderate microtubule stabilization decreased scar formation after spinal cord injury in rodents through various cellular mechanisms, including dampening of transforming growth factor-beta signaling. It prevented accumulation of chondroitin sulfate proteoglycans and rendered the lesion site permissive for axon regeneration of growth-competent sensory neurons. Microtubule stabilization also promoted growth of central nervous system axons of the Raphe-spinal tract and led to functional improvement. Thus, microtubule stabilization reduces fibrotic scarring and enhances the capacity of axons to grow.

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Language(s): eng - English
 Dates: 2011-02-18
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 558407
ISI: 000287455100062
 Degree: -

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Title: Science
  Alternative Title : Science
Source Genre: Journal
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Publ. Info: WASHINGTON : AMER ASSOC ADVANCEMENT SCIENCE
Pages: - Volume / Issue: 331 (6019) Sequence Number: - Start / End Page: 928 - 931 Identifier: ISSN: 0036-8075