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  Microtubule Stabilization Reduces Scarring and Causes Axon Regeneration After Spinal Cord Injury

Hellal, F., Hurtado, A., Ruschel, J., Flynn, K. C., Laskowski, C. J., Umlauf, M., et al. (2011). Microtubule Stabilization Reduces Scarring and Causes Axon Regeneration After Spinal Cord Injury. Science, 331(6019), 928-931.

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Datensatz-Permalink: https://hdl.handle.net/11858/00-001M-0000-0012-1F06-4 Versions-Permalink: https://hdl.handle.net/11858/00-001M-0000-0012-1F07-2
Genre: Zeitschriftenartikel

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 Urheber:
Hellal, F.1, Autor           
Hurtado, A.2, Autor
Ruschel, J.1, Autor           
Flynn, K. C.1, Autor           
Laskowski, C. J.1, Autor           
Umlauf, M.3, Autor
Kapitein, L. C.2, Autor
Strikis, D.2, Autor
Lemmon, V.2, Autor
Bixby, J.2, Autor
Hoogenraad, C. C.2, Autor
Bradke, F.1, Autor           
Affiliations:
1Max Planck Research Group: Axonal Growth and Regeneration / Bradke, MPI of Neurobiology, Max Planck Society, ou_1113553              
2[Hurtado, Andres] Johns Hopkins Univ, Hugo W Moser Res Inst Kennedy Krieger, Int Ctr Spinal Cord Injury, Dept Neurol, Baltimore, MD 21205 USA.; [Kapitein, Lukas C.; Hoogenraad, Casper C.] Erasmus MC, Dept Neurosci, NL-3000 CA Rotterdam, Netherlands.; [Kapitein, Lukas C.; Hoogenraad, Casper C.] Univ Utrecht, Fac Sci, NL-3584 CH Utrecht, Netherlands.; [Strikis, Dinara; Lemmon, Vance; Bixby, John] Univ Miami, Miller Sch Med, Miami Project Cure Paralysis, Miami, FL 33136 USA., ou_persistent22              
3Max Planck Society, ou_persistent13              

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 Zusammenfassung: Hypertrophic scarring and poor intrinsic axon growth capacity constitute major obstacles for spinal cord repair. These processes are tightly regulated by microtubule dynamics. Here, moderate microtubule stabilization decreased scar formation after spinal cord injury in rodents through various cellular mechanisms, including dampening of transforming growth factor-beta signaling. It prevented accumulation of chondroitin sulfate proteoglycans and rendered the lesion site permissive for axon regeneration of growth-competent sensory neurons. Microtubule stabilization also promoted growth of central nervous system axons of the Raphe-spinal tract and led to functional improvement. Thus, microtubule stabilization reduces fibrotic scarring and enhances the capacity of axons to grow.

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Sprache(n): eng - English
 Datum: 2011-02-18
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: eDoc: 558407
ISI: 000287455100062
 Art des Abschluß: -

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Titel: Science
  Alternativer Titel : Science
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: WASHINGTON : AMER ASSOC ADVANCEMENT SCIENCE
Seiten: - Band / Heft: 331 (6019) Artikelnummer: - Start- / Endseite: 928 - 931 Identifikator: ISSN: 0036-8075