English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Tailor-made inflammation: how neutrophil serine proteases modulate the inflammatory response

Kessenbrock, K., Dau, T., & Jenne, D. E. (2011). Tailor-made inflammation: how neutrophil serine proteases modulate the inflammatory response. Journal of Molecular Medicine-JMM, 89(1), 23-28.

Item is

Files

show Files

Locators

show

Creators

show
hide
 Creators:
Kessenbrock, K.1, Author              
Dau, T.1, Author              
Jenne, D. E.1, Author              
Affiliations:
1Department: Neuroimmunology / Wekerle, MPI of Neurobiology, Max Planck Society, ou_1113547              

Content

show
hide
Free keywords: Neutrophil serine proteases; Inflammation; Neutrophil elastase; Proteinase 3; Cathepsin G; Progranulin
 Abstract: Neutrophil granulocytes are important mediators of innate immunity, but also participate in the pathogenesis of (auto)inflammatory diseases. Neutrophils express a specific set of proteolytic enzymes, the neutrophil serine proteases (NSPs), which are stored in cytoplasmic granules and can be secreted into the extra- and pericellular space upon cellular activation. These NSPs, namely cathepsin G (CG), neutrophil elastase (NE), and proteinase 3 (PR3), have early been implicated in bacterial defense. However, NSPs also regulate the inflammatory response by specifically altering the function of cytokines and chemokines. For instance, PR3 and NE both inactivate the anti-inflammatory mediator progranulin, which may play a role in chronic inflammation. Here, we provide a concise update on NSPs as modulators of inflammation and discuss the biological and pathological significance of this novel function of NSPs. Mounting evidence support an important proinflammatory function for PR3, which may have been underestimated in the past.

Details

show
hide
Language(s): eng - English
 Dates: 2011-01
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 561299
ISI: 000288363200004
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Journal of Molecular Medicine-JMM
  Alternative Title : J. Mol. Med.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: NEW YORK : SPRINGER
Pages: - Volume / Issue: 89 (1) Sequence Number: - Start / End Page: 23 - 28 Identifier: ISSN: 0946-2716