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  Extracellular matrix in multiple sclerosis lesions: Fibrillar collagens, biglycan and decorin are upregulated and associated with infiltrating immune cells

Mohan, H., Krumbholz, M., Sharma, R., Eisele, S., Junker, A., Sixt, M., et al. (2010). Extracellular matrix in multiple sclerosis lesions: Fibrillar collagens, biglycan and decorin are upregulated and associated with infiltrating immune cells. Brain Pathology, 20(5), 966-975.

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 Creators:
Mohan, H.1, Author           
Krumbholz, M.1, Author           
Sharma, R.2, Author
Eisele, S.1, Author           
Junker, A.1, Author           
Sixt, M.2, Author
Newcombe, J.2, Author
Wekerle, H.1, Author           
Hohlfeld, R.1, Author           
Lassmann, H.2, Author
Meinl, E.1, Author           
Affiliations:
1Department: Neuroimmunology / Wekerle, MPI of Neurobiology, Max Planck Society, ou_1113547              
2[Sixt, Michael] Max Planck Inst Biochem, Dept Mol Med, D-8033 Martinsried, Germany.; [Sharma, Rakhi; Lassmann, Hans] Med Univ Vienna, Ctr Brain Res, Vienna, Austria.; [Newcombe, Jia] UCL Inst Neurol, London, England., ou_persistent22              

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Free keywords: extracellular matrix; inflammation; multiple sclerosis; neuroimmunology
 Abstract: Extracellular matrix (ECM) proteins can modify immune reactions, e.g. by sequestering or displaying growth factors and by interacting with immune and glial cells. Here we quantified by quantitative polymerase chain reaction (qPCR) expression of 50 ECM components and 34 ECM degrading enzymes in multiple sclerosis (MS) active and inactive white matter lesions. COL1A1, COL3A1, COL5A1 and COL5A2 chains were induced strongly in active lesions and even more in inactive lesions. These chains interact to form collagen types I, III and V, which are fibrillar collagens. Biglycan and decorin, which can decorate fibrillar collagens, were also induced strongly. The fibrillar collagens, biglycan and decorin were largely found between the endothelium and astrocytic glia limitans in the perivascular space where they formed a meshwork which was closely associated with infiltrating immune cells. In active lesions collagen V was also seen in the heavily infiltrated parenchyma. Fibrillar collagens I and III inhibited in vitro human monocyte production of CCL2 (MCP-1), an inflammatory chemokine involved in recruitment of immune cells. Together, ECM changes in lesions with different activities were quantified and proteins forming a perivascular fibrosis were identified. Induced fibrillar collagens may contribute to limiting enlargement of MS lesions by inhibiting the production of CCL2 by monocytes.

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Language(s): eng - English
 Dates: 2010-09
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 493355
ISI: 000280629400009
 Degree: -

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Title: Brain Pathology
  Other : Brain Pathol.
Source Genre: Journal
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Publ. Info: Zürich, Switzerland : International Society of Neuropathology
Pages: - Volume / Issue: 20 (5) Sequence Number: - Start / End Page: 966 - 975 Identifier: ISSN: 1015-6305
CoNE: https://pure.mpg.de/cone/journals/resource/954925585260