English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Axo-glial antigens as targets in multiple sclerosis: implications for axonal and grey matter injury

Derfuss, T., Linington, C., Hohlfeld, R., & Meinl, E. (2010). Axo-glial antigens as targets in multiple sclerosis: implications for axonal and grey matter injury. Journal of Molecular Medicine, 88(8), 753-761.

Item is

Files

show Files

Locators

show

Creators

show
hide
 Creators:
Derfuss, T.1, Author              
Linington, C.1, Author              
Hohlfeld, R.1, Author              
Meinl, E.1, Author              
Affiliations:
1Department: Neuroimmunology / Wekerle, MPI of Neurobiology, Max Planck Society, ou_1113547              

Content

show
hide
Free keywords: Multiple sclerosis; Neurofascin; Contactin-2; Grey matter injury; Cortical lesions; Node of Ranvier
 Abstract: Multiple sclerosis is thought to be an autoimmune-mediated disease of the central nervous system. For many years, T-cells were regarded as the key players in the pathogenesis, and myelin of white matter was considered as the main victim. However, research during recent years showed a more complex picture. Besides T-cells, also B-cells, antibodies and the innate immunity contribute to the tissue damage. Modern imaging techniques and neuropathological examinations showed that not only myelin but also axons, cortical neurons and nodes of Ranvier are damaged. The autoimmune targets of this widespread injury are so far not known. The identification of the axo-glial proteins contactin-2 and neurofascin provides excellent examples how antibodies can induce axonal injury at the node of Ranvier and how T-cells can destruct cortical integrity. This review will discuss the pathogenic implications of an autoimmune response against these newly discovered antigens.

Details

show
hide
Language(s): eng - English
 Dates: 2010-08
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 479818
ISI: 000279685300003
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Journal of Molecular Medicine
  Alternative Title : J. Mol. Med.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 88 (8) Sequence Number: - Start / End Page: 753 - 761 Identifier: ISSN: 0946-2716